Discover ioMicroglia

Register your interest below!

ioMicroglia early access vials are available now

ioMicroglia are cryopreserved human iPSC-derived microglia powered by bit.bio’s opti-ox™ precision reprogramming technology, built so scientists no longer have to battle with long differentiation protocols that produce inconsistent cell populations.


In just 10 days post-revival, ioMicroglia show:

  • a typical ramified morphology
  • consistent and defined cell populations
  • expression of key phenotypic markers (TMEM119, P2RY12, IBA1, CX3CR1, CD11b, CD45, and CD14)
  • a transcriptomic signature with high equivalence to primary adult and foetal microglia
  • typical microglial functions including phagocytosis (amyloid beta (1-42), apoptotic cells and bacteria) and proinflammatory cytokine secretion (IL-6 and TNFα), upon stimulation
  • co-culture compatibility with ioGlutamatergic Neurons, whilst maintaining their function

 

ioMicroglia are ready for co-culture experiments with neurons in just 10 days

HubSpot Video

Cryopreserved ioMicroglia and ioGlutamatergic Neurons were thawed and cultured independently for 10 days before being co-cultured for 8 days. Imaging was then performed in 30-minute intervals. ioMicroglia form a stable co-culture with ioGlutamatergic Neurons.

HubSpot Video

Cryopreserved ioMicroglia and ioGlutamatergic Neurons were thawed and cultured independently for 10 days before being co-cultured for 8 days. Imaging was then performed in 30-minute intervals. A. ioMicroglia form a stable co-culture with ioGlutamatergic Neurons. B. In co-culture, ioMicroglia perform phagocytosis of pHrodo™ labelled Zymosan A BioParticles™ (red colour).

ioMicroglia features that inspire confidence

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Quick

Ready-to-use in just 10 days!

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Easy to use

Cryopreserved cells arrive programmed to rapidly mature on arrival.

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Defined

>90% of cells express key phenotypic markers.

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Consistent

Reproducible results across batches confirmed with scRNA-seq.

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Functional

Upon stimulation, ioMicroglia perform phagocytosis and secrete cytokines.

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Co-culture compatible

Suitable for co-culture studies with neurons.

 

Can't wait to get your hands on ioMicroglia?

Fill out the form to register your interest now, and our team will be in touch with further details about our ioMicroglia Early Access Program.