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The development of synthetic super-enhancers (SSEs) engineered with robust activity and high selectivity for the core transcriptional regulatory network in glioblastoma stem cells (GSCs)
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How GSC-selective expression of cytotoxic and immunomodulatory payloads, delivered using adeno-associated virus vectors, led to curative outcomes in a mouse model of aggressive glioblastoma
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How ioGlutamatergic Neurons, ioGABAergic Neurons and ioMicroglia were used