Modelling Alzheimer's disease with human iPSC-derived cells


Consistent, defined and scalable human iPSC-derived disease models for Alzheimer's disease research and drug discovery

Powered by opti-ox™ 


Alzheimer's disease, the most common type of dementia, is a neurodegenerative disorder that progressively undermines patients' cognitive abilities, impairing their capacity to create and retrieve memories. Studying Alzheimer’s disease remains a significant challenge, in part because of difficulties accurately emulating the disease's pathophysiology in vitro.

There is a pressing need for an in vitro model of Alzheimer's disease that can be used to accurately and reliably study the effect of disease-associated mutations, disease progression and to identify potential therapeutic targets. ioDisease Model Cells™ provide scientists with defined, consistent and scalable human iPSC-derived cells engineered with common monogenic Alzheimer’s disease-related mutations, helping improve the translatability of in vitro research. 

Discover ioDisease Model Cells for modelling Alzheimer’s disease in vitro below.

Alzheimer's disease models in ioGABAergic Neurons 

ioGABAergic Neurons APP V717I/WT™ ioDisease Model Cells
ioGABAergic Neurons APP V717I/WT™ cat no. io1084 | io1085
Order now
ioGABAergic Neurons APP V717I/V717I™ ioDisease Model Cells
ioGABAergic Neurons APP V717I/V717I™ cat no. io1081 | io1082
Order now

Alzheimer's disease models in ioMicroglia

ioMicroglia TREM2 R47H/WT™ ioDisease Model Cells
ioMicroglia TREM2 R47H/WT™ cat no. io1038
Order now
ioMicroglia TREM2 R47H/R47H™ ioDisease Model Cells
ioMicroglia TREM2 R47H/R47H™ cat no. io1035 | io1036
Order now
ioMicroglia APOE 4/3 C112R/WT™ ioDisease Model Cells
ioMicroglia APOE 4/3 C112R/WT™ cat no. io1033 | io1034
Order now
ioMicroglia APOE 4/4 C112R/C112R™ ioDisease Model Cells
ioMicroglia APOE 4/4 C112R/C112R™ cat no. io1031 | io1032
Order now

Pair ioDisease Model Cells with a genetically matched control

ioMicroglia™ ioWild Type Cells
ioMicroglia™ cat no. io1021
Order now
ioGABAergic Neurons™ ioWild Type Cells
ioGABAergic Neurons™ cat no. io1003
Order now

Generate your own Alzheimer's disease-related gene knockouts with ioCRISPR-Ready Cells™ 

Generate any knockout mutation related to Alzheimer's disease with ioCRISPR-Ready Cells. These cells have Cas9 constitutively expressed, enabling scientists to easily knockout their gene of interest in physiologically relevant cells in a matter of days.

ioGlutamatergic-Neurons-CRISPR-Ready-Hero-Image square

Don’t see what you’re looking for? Partner with us to generate custom ioDisease Model Cells to study Alzheimer's disease

Access our platform to generate custom ioCells to precisely answer your drug discovery and disease research questions.

Giving you easy access to the best cells-1

Related pages

Discover ioCells Learn about our range of human iPSC-derived cells for research and drug discovery
Resources Explore our latest scientific insights, webinars, blogs and videos
Our platform Discover the cell identity coding platform behind our cells