Driving experimental reproducibility and lot-to-lot biological consistency in human iPSC-derived cells enabled by opti-ox technology

opti-ox technology has been successfully applied to deterministically cell program a range of human cell types from hiPSC. The resulting highly defined, homogeneous cell populations can be used as physiologically relevant cell models for research and drug discovery.

The generated cell populations show high levels of consistency across different manufactured lots, as evidenced by morphology, key marker expression and functional activity data. Furthermore, whole transcriptome analysis reveals how different users, manufacturing lots, and time periods do not affect the consistency of the cell populations.

The availability of a consistent source of hiPSC-derived cells has the potential to address the lack of experimental variability and reproducibility seen across research, allowing scientists to have higher confidence in their experimental findings.