Platelet-rich plasma modulates neuroinflammation in an iPSC model of sensory neurons and microglia

Read the publication to explore:

• The establishment of a direct co-culture of human iPSC-derived sensory neurons and microglia, stimulated with IFN-gamma and LPS, as an in vitro model of neuroinflammation

• A comparison of standard platelet-rich plasma (sPRP) and balanced protein-concentrate plasma (BPCP), enriched in extraplatelet molecules, in modulating neuroinflammation, microglial activation, apoptosis and neuronal plasticity

• How BPCP reduced pro-inflammatory cytokines (IL-6, IL-8, MCP-1) more than sPRP, while downregulating microglial activation and apoptotic markers

• How sPRP promoted inflammation resolution and neuroprotection, upregulating IL-10 and TGF-β1 and partially restoring KCC2 (SLC12A5) expression

• How ioSensory Neurons and ioMicroglia were used