Read the publication to explore:
-
The modulation and disruption of human brain organoid rhythms by brain-permeant drugs and mistimed cortisol exposure
-
Evidence that human brain cells develop intrinsic circadian oscillations that may not be fully explained by canonical clockwork mechanisms
-
The validation of 2D and 3D human neural cultures as tractable models for investigating the circadian neural clockwork and brain health
Rzechorzek, et al
bioRxiv
2024
Featuring opti-ox enabled microglia male iPS cell line and opti-ox enabled glutamatergic neurons iPS cell line