iPSC-derived Alzheimer's disease models show increased secretion of pathogenic amyloid beta peptides in glutamatergic neurons and responses to amyloid beta 42 in microglia

You will learn:

• ioGlutamatergic Neurons carrying PSEN1 M146L, APP V717I or KM670/671NL mutations were characterised as Alzheimer’s disease models and compared to their wild type, genetically matched control. The disease model cells were shown to recapitulate the changes in Aβ ratios observed in Alzheimer’s disease patients.

• ioMicroglia and APOE genetic risk models demonstrate the key functional phenotypes of phagocytosis and cytokine response.

• This panel of wild type and Alzheimer’s disease model cells can be co-cultured in multiple combinations, enabling the modelling of complex cellular interactions in Alzheimer’s disease.