Human iPSC-derived neurons

Consistent, defined and scalable human iPSC-derived neurons for neurodegeneration, neurophysiology, and neurodevelopmental research

Nerve cells, also known as neurons are the fundamental units of the brain and nervous system, responsible for receiving and transmitting information throughout the body. Rich with multiple neuronal cell types and varied glial cells, neural tissue has historically been difficult to model in vitro [1]. Such modelling challenges greatly slow our progress in understanding and treating neurodegenerative disease. Fortunately, this is changing with recent advances in induced pluripotent stem cell (iPSC) technology. 

bit.bio’s deterministic cell programming technology (known as opti-ox™) enables the rapid conversion of entire cultures of stem cells into a precise cell identity with unprecedented consistency. The rapid gain of functionality of bit.bio’s human nerve cells empower researchers to build the types of physiologically relevant in vitro models needed to drive research into neurodegenerative disease and neuropsychiatric disorders, and the data-backed lot-to-lot consistency enables standardisation across assays used in early stages of drug discovery, from target identification to clinical translation.

Additionally, the development of CRISPR-Ready neurons makes it possible to perform functional genomic screening in human iPSC-derived neurons, opening the door to more efficient and physiologically relevant target identification and validation studies. Unlike primary neurons that often lack suitable controls, our range of ioCells includes disease models with engineered disease-specific mutations and genetically matched controls. Having access to defined, human iPSC-derived neurons that emulate neurodegenerative disease will help accelerate progress in understanding and ultimately treating these devastating diseases.  

Elevate your research with bit.bio’s human iPSC-derived neurons, from CRISPR-Ready glutamatergic neurons to ALS-specific motor neurons.

ioWild Type Cells

ioWild Type Cells

ioGABAergic Neurons cat no | io1003

ioWild Type Cells

ioGlutamatergic Neurons cat no | io1001

ioWild Type Cells

ioSensory Neurons cat no | io1024

ioWild Type Cells

ioMotor Neurons cat no | io1027

Engineered to meet your workflow with our toolkit of ioDisease Model Cells and CRISPR-Ready ioCells

CRISPR-Ready ioCells

CRISPRko-Ready ioGlutamatergic Neurons cat no | io1090

ioDisease Model Cells

ioGABAergic Neurons APP V717I/WT cat no | io1084 | io1085

ioDisease Model Cells

ioGABAergic Neurons APP V717I/V717I cat no | io1081 | io1082

ioDisease Model Cells

ioMotor Neurons TDP-43 M337V/WT cat no | io1050

ioDisease Model Cells

ioMotor Neurons TDP-43 M337V/M337V cat no | io1046

ioDisease Model Cells

ioGlutamatergic Neurons HTT 50CAG/WT cat no | ioEA1004

ioDisease Model Cells

ioMotor Neurons SOD-1 G93A/WT cat no | io1042

ioDisease Model Cells

ioMotor Neurons SOD-1 G93A/G93A cat no | io1041

ioDisease Model Cells

ioMotor Neurons FUS P525L/WT cat no | io1055

ioDisease Model Cells

ioMotor Neurons FUS P525L/P525L cat no | io1052

ioDisease Model Cells

New! ioMotor Neurons TDP-43 A382T/WT cat no | io6019

ioDisease Model Cells

New! ioMotor Neurons TDP-43 N352S/WT cat no | io6017

ioDisease Model Cells

ioGlutamatergic Neurons TDP-43 M337V/M337V cat no | ioEA1005

ioDisease Model Cells

ioGlutamatergic Neurons TDP-43 M337V/WT cat no | ioEA1006

ioDisease Model Cells

ioGlutamatergic Neurons PRKN R275W/WT cat no | io1013

ioDisease Model Cells

ioGlutamatergic Neurons PRKN R275W/R275W cat no | io1020

ioDisease Model Cells

ioGlutamatergic Neurons SNCA A53T/A53T cat no | io1088

ioDisease Model Cells

ioGlutamatergic Neurons SNCA A53T/WT cat no | io6005

ioDisease Model Cells

ioGlutamatergic Neurons PSEN1 M146L/M146L cat no | io1069

ioDisease Model Cells

ioGlutamatergic Neurons PSEN1 M146L/WT cat no | io1072

ioDisease Model Cells

ioGlutamatergic Neurons APP V717I/WT cat no | io1067

ioDisease Model Cells

ioGABAergic Neurons APP V717I/V717I cat no | io1081 | io1082

ioDisease Model Cells

ioGlutamatergic Neurons APP KM670/671NL/WT cat no | io1061

ioDisease Model Cells

ioGlutamatergic Neurons APP V717I/V717I cat no | io1063

ioDisease Model Cells

ioGlutamatergic Neurons GBA null/R159W cat no | io1007

CRISPR-Ready ioCells

New! CRISPRa-Ready ioGlutamatergic Neurons cat no | io1099

CRISPR-Ready ioCells

New! CRISPRi-Ready ioGlutamatergic Neurons cat no | io1098

Producing 3D Neuronal Microtissues for Preclinical Drug Screening using ioGlutamatergic Neurons

Dive into this application note, to discover how ioGlutamatergic Neurons and iPSC-derived astrocytes have been used in 3D microtissues, to build a powerful model system for medium- to high-throughput drug screening and more productive preclinical drug development.

Download application note

Product resources

(LinkedValues: [{hs_name=Developing next-generation in vitro phenotypic assays for Huntington’s disease by combining a precision reprogrammed hiPSC-derived disease model with high-density microelectrode arrays, hs_id=161727133271, hs_path=ioglutamatergic-neurons-htt-maxwell-crl, button_label=null, button_link=null, type={label=Application note, value=Application note}, thumbnail={alt_text=, width=600, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Product%20pages/ioGlutamatergic%20Neurons%20HTT%2050CAGWT/a-HTT50CAGWT_Overlay__TUBB3(G)_MAP2(R)_DAPI(B)_%20(1).png, height=378}, year={label=2022, value=2022}, summary=<p>bit.bio | MaxWell Biosystems | Charles River Laboratories</p> <p>2022</p>, date_published=1708560000000, sort_date=1668556800000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioGlutamatergic Neurons HTT 50CAG/WT, value=ioGlutamatergic Neurons HTT 50CAG/WT}], media_contact=<p>bit.bio | MaxWell Biosystems | Charles River Laboratories</p> <p>2022</p> <p>&nbsp;</p>, listing_button_label=Download}, {hs_name=Sartorius application note - Advanced in vitro Modeling of Human iPSC-derived Neuronal Mono- and Co-cultures with Microglia, hs_id=177620758074, hs_path=sartorius-application-note-advanced-in-vitro-modeling-of-human-ipsc-derived-neuronal-mono-and-co-cultures-with-microglia, button_label=null, button_link=null, type={label=Application note, value=Application note}, thumbnail={alt_text=co culture low density progenitors compressed, width=1732, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Product%20pages/ioMicroglia/co%20culture%20low%20density%20progenitors%20compressed.png, height=970}, year={label=2024, value=2024}, summary=Trigg et al.,<br>Sartorius<br>2024, date_published=1725580800000, sort_date=1725580800000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioMicroglia, value=ioMicroglia}, {label=ioGlutamatergic Neurons HTT 50CAG/WT, value=ioGlutamatergic Neurons HTT 50CAG/WT}], media_contact=Trigg et al.,<br>Sartorius<br>2024, listing_button_label=Download}, {hs_name=Producing 3D Neuronal Microtissues for Preclinical Drug Screening using ioGlutamatergic Neurons, hs_id=180505546901, hs_path=glutamatergic-neuron-3d-neuronal-microtissues-inventia, button_label=null, button_link=null, type={label=Application note, value=Application note}, thumbnail={alt_text=bitbio-ioGlutamatergic-Neurons, width=1700, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Product%20pages/ioGlutamatergic%20Neurons/bitbio-ioGlutamatergic-Neurons.jpg, height=1300}, year={label=2024, value=2024}, summary=V1<br>2024<br>bit.bio<br>Inventia, date_published=1728345600000, sort_date=1728345600000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioAstrocytes, value=ioastrocytes}], media_contact=V1<br>2024<br>bit.bio<br>Inventia, listing_button_label=Download}, {hs_name=Characterisation of ioSensory Neurons on the Patchliner, hs_id=181776418229, hs_path=characterisation-of-iosensory-neurons-on-the-patchliner, button_label=null, button_link=null, type={label=Application note, value=Application note}, thumbnail={alt_text=nanion-application-note, width=1080, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Resources/Application%20Notes/nanion-application-note.png, height=1080}, year={label=2024, value=2024}, summary=<p>V1<br>A Obergrussberger et al, 2024.<br>Nanion</p>, date_published=1729641600000, sort_date=1729641600000, tags=[{label=ioSensory Neurons, value=ioSensory Neurons}], media_contact=<p style="line-height: 1;">V1</p> <p style="line-height: 1;">A Obergrussberger et al, 2024.</p> <p style="line-height: 1;">Nanion</p>, listing_button_label=Download}, {hs_name=Generating publishable neuroscience research in 12 weeks with ioGlutamatergic Neurons, hs_id=161746296926, hs_path=generating-publishable-neuroscience-research-in-12-weeks-with-glutamatergic-neurons, button_label=null, button_link=null, type={label=Case study, value=Case study}, thumbnail={alt_text=, width=2400, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Compressed%20Photos%20and%20Gifs/bit.bio_case_study_Pic0012_WebRes.jpg, height=1600}, year={label=2024, value=2024}, summary=<p>Professor Deepak Srivastava</p> <p>Professor of Molecular Neuroscience and Group Leader, MRC Centre for Developmental Disorders</p> <p>King’s College London&nbsp;</p>, date_published=1710720000000, sort_date=1705276800000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}], media_contact=<p>V2</p> <p>2024</p> <p>bit.bio</p>, listing_button_label=Download}, {hs_name=ioGlutamatergic Neurons , hs_id=161746296923, hs_path=glutamatergic-neurons, button_label=View brochure, button_link=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Resources/Brochures/bit.bio-ioGlutamatergic%20Neurons-Brochure.pdf, type={label=Brochure, value=Brochure}, thumbnail={alt_text=, width=2550, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Discover%20ioCells/iowild-type/bit.bio-ioGlutamatergic-Neurons-Day-14-Beta-III-Tubulin-staining-banner.jpg, height=1791}, year={label=2024, value=2024}, summary=<p>bit.bio</p>, date_published=1713312000000, sort_date=1713312000000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioAstrocytes, value=ioAstrocytes}, {label=Product information, value=Product information}], media_contact=null, listing_button_label=Download}, {hs_name=ioSensory Neurons, hs_id=164676247915, hs_path=sensory-neurons, button_label=View brochure, button_link=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Resources/Brochures/bit.bio-ioSensory%20Neuron-Brochure.pdf, type={label=Brochure, value=Brochure}, thumbnail={alt_text=www.bit.biohubfsWebsite contentProduct pagesioSensory NeuronsioSensory hero image-2, width=980, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/social-suggested-images/www.bit.biohubfsWebsite%20contentProduct%20pagesioSensory%20NeuronsioSensory%20hero%20image-2.png, height=1102}, year={label=2024, value=2024}, summary=bit.bio, date_published=1713312000000, sort_date=1713312000000, tags=[{label=ioSensory Neurons, value=ioSensory Neurons}, {label=Product information, value=Product information}], media_contact=null, listing_button_label=Download}, {hs_name=ioMotor Neurons, hs_id=164676247920, hs_path=motor-neurons, button_label=View brochure, button_link=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Resources/Brochures/bitbio-ioMotor_Neuron-Brochure.pdf, type={label=Brochure, value=Brochure}, thumbnail={alt_text=resized for Cell-fie iomotor_neuron_HERO_ICC_top_CROP2, width=260, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Emails/Cell-fie/resized%20for%20Cell-fie%20iomotor_neuron_HERO_ICC_top_CROP2.png, height=172}, year={label=2024, value=2024}, summary=bit.bio, date_published=1713312000000, sort_date=1713312000000, tags=[{label=ioMotor Neurons, value=ioMotor Neurons}, {label=Product information, value=Product information}], media_contact=null, listing_button_label=Download}, {hs_name=Comparing Stem Cells Differentiation Methods | Infographic, hs_id=161703352713, hs_path=differentiating-ipsc-which-approach-works-best, button_label=View infographic, button_link=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Resources/bit.bio_Infographic_Differentiating%20iPSCs%20which%20approach%20works%20best%20-%202023.pdf, type={label=Infographic, value=Infographic}, thumbnail={alt_text=, width=1200, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Bit-bio%20Resources%20-%20Image%20Infographic_Differentiating%20iPSCs%20v3-comp.jpg, height=726}, year={label=2022, value=2022}, summary=<p>bit.bio</p>, date_published=1707782400000, sort_date=1658448000000, tags=[{label=ioGABAergic Neurons, value=ioGABAergic Neurons}, {label=Product information, value=Product information}, {label=ioGlutamatergic Neurons TDP-43 M337V Het, value=ioGlutamatergic Neurons TDP-43 M337V Het}, {label=ioGlutamatergic Neurons TDP-43 M337V Hom, value=ioGlutamatergic Neurons TDP-43 M337V Hom}], media_contact=null, listing_button_label=View}, {hs_name=High Content Analysis of 2D and 3D cellular models for target and phenotypic drug discovery, hs_id=161961134487, hs_path=charles-river-poster-high-content-analysis-of-cellular-models, button_label=View poster, button_link=https://bit.bio/hubfs/BitBio_April2021/pdf%20link/2020_Lachize-et-al_High-Content-Analysis-of-2D-and-3D-Cellular-Models_Charles-River.pdf, type={label=Poster, value=Poster}, thumbnail={alt_text=, width=1700, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Product%20pages/ioGlutamatergic%20Neurons/bitbio-ioGlutamatergic-Neurons.jpg, height=1300}, year={label=2020, value=2020}, summary=<p>Lachize, et al</p> <p>Courtesy of Charles River Laboratories</p> <p>2020</p>, date_published=1706313600000, sort_date=1602806400000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}], media_contact=null, listing_button_label=View}, {hs_name=Development and characterisation of a robust in vitro disease model to study tauopathies, hs_id=161961134488, hs_path=ftd-mapt-phenotype-poster-charles-river-mar23, button_label=View poster, button_link=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Resources/SFN2022-Development-and-characterization-of-a-robust-in-vitro-disease-model-to-study-tauopathies.pdf, type={label=Poster, value=Poster}, thumbnail={alt_text=, width=1000, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Product%20pages/MAPT%20P301S/MAPT%20P301SP301S%20final%20homepage%20image.jpg, height=1400}, year={label=2022, value=2022}, summary=<p>Ritsma, et al</p> <p>Charles River Laboratories &amp; bit.bio</p> <p>2022</p>, date_published=1708646400000, sort_date=1678924800000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioGlutamatergic Neurons MAPT P301S/WT, value=ioGlutamatergic Neurons MAPT P301S/WT}, {label=ioGlutamatergic Neurons MAPT P301S/P301S, value=ioGlutamatergic Neurons MAPT P301S/P301S}, {label=ioGlutamatergic Neurons MAPT N279K/WT, value=ioGlutamatergic Neurons MAPT N279K/WT}], media_contact=null, listing_button_label=View}, {hs_name=Rapid and consistent generation of functional microglia from reprogrammed hiPSCs to study neurodegeneration and neuroinflammation, hs_id=161961134491, hs_path=poster-rapid_and_consistent_generation_of_functional_ipsc_derived_microglia, button_label=View poster, button_link=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Product%20pages/ioMicroglia/bitbio-ioMicroglia_poster-V7-press_SfN%202022.pdf, type={label=Poster, value=Poster}, thumbnail={alt_text=, width=1504, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Emails/Header%20images/Header%20Images%20-%20ICC%20only/Microglia%20blog%20email%20header%20format.png, height=850}, year={label=2022, value=2022}, summary=<p>Raman, et al</p> <p>bit.bio</p> <p>2022</p>, date_published=1709251200000, sort_date=1669680000000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioMicroglia, value=ioMicroglia}], media_contact=null, listing_button_label=View}, {hs_name=Modelling neurodegeneration: Human isogenic system to study FTD & ALS, hs_id=161961134492, hs_path=ftd-als-mapt-tdp-43-disease-models-adpd-2023-poster-mar23, button_label=View poster, button_link=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Resources/bitbio_ioGlutamatergic%20Neurons%20MAPT%20TDP-43%20Disease%20Model%20poster_v2.pdf, type={label=Poster, value=Poster}, thumbnail={alt_text=, width=1966, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Product%20pages/MAPT%20N279K/N279K%20MAP2%20brightfield%20compressed%20rotated.png, height=1966}, year={label=2023, value=2023}, summary=<p>Oosterveen, et al</p> <p>bit.bio &amp; Charles River Laboratories</p> <p>2023</p>, date_published=1709424000000, sort_date=1687478400000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioGlutamatergic Neurons HTT 50CAG/WT, value=ioGlutamatergic Neurons HTT 50CAG/WT}, {label=ioGlutamatergic Neurons TDP-43 M337V Het, value=ioGlutamatergic Neurons TDP-43 M337V Het}, {label=ioGlutamatergic Neurons TDP-43 M337V Hom, value=ioGlutamatergic Neurons TDP-43 M337V Hom}, {label=ioGlutamatergic Neurons MAPT P301S/WT, value=ioGlutamatergic Neurons MAPT P301S/WT}, {label=ioGlutamatergic Neurons MAPT P301S/P301S, value=ioGlutamatergic Neurons MAPT P301S/P301S}, {label=ioGlutamatergic Neurons MAPT N279K/WT, value=ioGlutamatergic Neurons MAPT N279K/WT}], media_contact=null, listing_button_label=View}, {hs_name=Rapid and consistent generation of functional motor neurons from reprogrammed human iPSCs using opti-ox technology, hs_id=161961134494, hs_path=iomotor-neurons-sfn-2023-poster, button_label=null, button_link=null, type={label=Poster, value=Poster}, thumbnail={alt_text=, width=2164, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Product%20pages/ioMotor%20Neurons/iomotor_neuron_HERO_ICC_top_CROP2_COMPRESS.png, height=2841}, year={label=2023, value=2023}, summary=<p>Vaquero, et al</p> <p>bit.bio</p> <p>2023</p>, date_published=1710547200000, sort_date=1701820800000, tags=[{label=ioMotor Neurons, value=ioMotor Neurons}], media_contact=<p><span>Vaquero, et al</span></p> <p><span>bit.bio</span></p> <p><span>2023</span></p>, listing_button_label=Download}, {hs_name=Generation and characterisation of a panel of human iPSC-derived neurons and microglia carrying early and late onset relevant mutations for Alzheimer’s disease, hs_id=161961134495, hs_path=slas2024-ad-poster, button_label=null, button_link=null, type={label=Poster, value=Poster}, thumbnail={alt_text=, width=1800, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Product%20pages/ioMicroglia/Microglia%20hero%202%20resize%20brighten%20v2%20compress.png, height=1800}, year={label=2024, value=2024}, summary=Smith, et al.&nbsp;<br>bit.bio<br>2024, date_published=1711065600000, sort_date=1708300800000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioGABAergic Neurons, value=ioGABAergic Neurons}, {label=ioMicroglia, value=ioMicroglia}], media_contact=Smith et al.&nbsp;<br>bit.bio<br>2024, listing_button_label=Download}, {hs_name=Rapid and consistent generation of functional motor neurons from reprogrammed human iPSCs using opti-ox technology, hs_id=164676247845, hs_path=poster-maxwell-2024-iomotor-neurons, button_label=null, button_link=null, type={label=Poster, value=Poster}, thumbnail={alt_text=iomotor_neuron_HERO_ICC_top_CROP2_COMPRESS, width=2164, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Product%20pages/ioMotor%20Neurons/iomotor_neuron_HERO_ICC_top_CROP2_COMPRESS.png, height=2841}, year={label=2024, value=2024}, summary=Foulser, et al&nbsp;<br>bit.bio<br>2024, date_published=1713312000000, sort_date=1713312000000, tags=[{label=ioMotor Neurons, value=ioMotor Neurons}], media_contact=Foulser, et al&nbsp;<br>bit.bio<br>2024, listing_button_label=Download}, {hs_name=Lipid-Bilayer-Supported 3D Printing of Human Cerebral Cortex Cells Reveals Developmental Interactions , hs_id=161968263464, hs_path=lipid-bilayer-supported-3d-printing-of-human-cerebral-cortex-cells-reveals-developmental-interactions, button_label=Read more, button_link=https://onlinelibrary.wiley.com/doi/10.1002/adma.202002183, type={label=Publication, value=Publication}, thumbnail={alt_text=, width=666, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/BitBio2022/Resources/Resource-thumbs/resized/New%20Project%20(13).jpeg, height=428}, year={label=2020, value=2020}, summary=<p>Zhou L, et al&nbsp;</p> <p><em>Advanced Science News</em></p> <p>2020</p> <p><a href="https://www.bit.bio/products/nerve-cells/glutamatergic-neurons-wild-type-io1001" rel="noopener" target="_blank">Using ioGlutamatergic Neurons</a></p>, date_published=1592092800000, sort_date=1598659200000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}], media_contact=<p>Zhou L, et al</p> <p><em>Advanced Science News</em></p> <p>2020</p> <p>Using <a href="https://www.bit.bio/glutamatergic-neurons" rel="noopener">ioGlutamatergic Neurons</a></p>, listing_button_label=Read more}, {hs_name=Reprogramming the stem cell for a new generation of cures, hs_id=161968263465, hs_path=reprogramming-the-stem-cell-for-a-new-generation-of-cures, button_label=Read more, button_link=https://www.ddw-online.com/reprogramming-the-stem-cell-for-a-new-generation-of-cures-1459-202004/, type={label=Publication, value=Publication}, thumbnail={alt_text=, width=2092, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/bit.bio%20ioGlutamatergic%20Neurons%202022.jpg, height=1584}, year={label=2020, value=2020}, summary=<p>Davenport A, Frolov T &amp; Kotter M</p> <p><em>Drug Discovery World</em></p> <p>2020</p> <p>&nbsp;</p> <p>&nbsp;</p>, date_published=1585872000000, sort_date=1597968000000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioSkeletal Myocytes, value=ioSkeletal Myocytes}, {label=ioGABAergic Neurons, value=ioGABAergic Neurons}, {label=ioMicroglia, value=ioMicroglia}, {label=ioSensory Neurons, value=ioSensory Neurons}, {label=ioMotor Neurons, value=ioMotor Neurons}, {label=ioAstrocytes, value=ioAstrocytes}], media_contact=<p><span>Davenport A, Frolov T &amp; Kotter M.</span></p> <p><em>Drug Discovery World</em></p> <p>2020</p> <p>&nbsp;</p> <p>&nbsp;</p>, listing_button_label=Read more}, {hs_name=Inducible and Deterministic Forward Programming of Human Pluripotent Stem Cells into Neurons, Skeletal Myocytes, and Oligodendrocytes , hs_id=161968263466, hs_path=inducible-and-deterministic-forward-programming-of-human-pluripotent-stem-cells, button_label=Read more, button_link=https://www.cell.com/stem-cell-reports/fulltext/S2213-6711(17)30083-8, type={label=Publication, value=Publication}, thumbnail={alt_text=, width=759, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/publication-Inducible-and-deterministic-colour.jpg, height=461}, year={label=2017, value=2017}, summary=<p>Pawlowski M et al<br><em>Stem Cell Reports</em></p> <p>2017</p>, date_published=1491868800000, sort_date=1499385600000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}], media_contact=<p><span>Pawlowski M, et al</span></p> <p><em>Stem Cell Reports</em></p> <p>2017</p> <p>&nbsp;</p>, listing_button_label=Read more}, {hs_name=Compounds co-targeting kinases in axon regulatory pathways promote regeneration and behavioral recovery after spinal cord injury in mice, hs_id=161968263467, hs_path=compounds-co-targeting-kinases-in-axon-regulatory-pathways-promote-regeneration-and-behavioral-recovery-after-spinal-cord-injury-in-mice, button_label=Read more, button_link=https://pubmed.ncbi.nlm.nih.gov/35588791/, type={label=Publication, value=Publication}, thumbnail={alt_text=, width=1871, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Resources/Publications/bit.bio_single%20image_ioGlutamatergic%20Neurons%20Mah%20et%20al%202022.jpg, height=1417}, year={label=2022, value=2022}, summary=<p>Mah, et al</p> <p><em>Experimental Neurology</em></p> <p>2022</p> <p>Using <a href="https://www.bit.bio/products/nerve-cells/glutamatergic-neurons-wild-type-io1001" rel="noopener" target="_blank">ioGlutamatergic Neurons</a></p>, date_published=1652659200000, sort_date=1667260800000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}], media_contact=<p>Mah, et al</p> <p><em>Experimental Neurology</em></p> <p>2022</p> <p>Using <a href="https://www.bit.bio/glutamatergic-neurons" rel="noopener">ioGlutamatergic Neurons</a></p>, listing_button_label=Read more}, {hs_name=Glutamatergic Neurons and Brain Cyst Formation , hs_id=161968263468, hs_path=glutamatergic-neurons-and-brain-cyst-formation, button_label=Read more, button_link=https://www.frontiersin.org/articles/10.3389/fcimb.2021.788303/full, type={label=Publication, value=Publication}, thumbnail={alt_text=, width=2092, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/bit.bio%20ioGlutamatergic%20Neurons%202022.jpg, height=1584}, year={label=2022, value=2022}, summary=<p>Bando, et al</p> <p><em>Frontiers in Cellular and Infection Microbiology</em></p> <p>2022</p> <p>Using<a href="https://www.bit.bio/products/nerve-cells/glutamatergic-neurons-wild-type-io1001" rel="noopener" target="_blank"> ioGlutamatergic Neurons</a></p> <p>&nbsp;</p> <p>&nbsp;</p>, date_published=1641859200000, sort_date=1667347200000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}], media_contact=<p>Bando, et al<br><br><em>Frontiers in Cellular and Infection Microbiology</em></p> <p>2022</p> <p>Using <a href="https://www.bit.bio/glutamatergic-neurons" rel="noopener">ioGlutamatergic Neurons</a></p>, listing_button_label=Read more}, {hs_name=Interferon-γ exposure of human iPSC-derived neurons alters major histocompatibility complex I and synapsin protein expression , hs_id=161968263469, hs_path=interferon-γ-exposure-of-human-ipsc-derived-neurons-alters-major-histocompatibility-complex-i-and-synapsin-protein-expression, button_label=Read more, button_link=https://www.frontiersin.org/articles/10.3389/fpsyt.2022.836217/full, type={label=Publication, value=Publication}, thumbnail={alt_text=, width=3742, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Resources/Publications/bit.bio%20ioGlutamatergic%20Neurons%20pavlinek%20et%20al%202022.jpg, height=2836}, year={label=2022, value=2022}, summary=<p>Pavinlek, et al</p> <p><em>Frontiers in Psychiatry</em></p> <p>2022</p> <p>Using <a href="https://www.bit.bio/products/nerve-cells/glutamatergic-neurons-wild-type-io1001" rel="noopener" target="_blank">ioGlutamatergic Neurons</a></p> <p>&nbsp;</p> <p>&nbsp;</p>, date_published=1663113600000, sort_date=1667433600000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}], media_contact=<p>Pavinlek, et al<br><br><em>Frontiers in Psychiatry</em></p> <p>2022</p> <p>Using <a href="https://www.bit.bio/glutamatergic-neurons" rel="noopener">ioGlutamatergic Neurons</a></p>, listing_button_label=Read more}, {hs_name=3D bioprinting of iPSC neuron-astrocyte coculture, hs_id=161968263471, hs_path=3d-bioprinting-of-ipsc-neuron-astrocyte-coculture, button_label=Read more, button_link=https://www.jove.com/t/65856/three-dimensional-bioprinting-human-ipsc-derived-neuron-astrocyte, type={label=Publication, value=Publication}, thumbnail={alt_text=, width=1700, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Product%20pages/ioGlutamatergic%20Neurons/bitbio-ioGlutamatergic-Neurons.jpg, height=1300}, year={label=2023, value=2023}, summary=<p>Whitehouse, et al<br><em>JoVE Journal of Visualized Experiments&nbsp;</em><br>2023</p> <p>Using <a href="https://www.bit.bio/products/nerve-cells/glutamatergic-neurons-wild-type-io1001" rel="noopener">ioGlutamatergic Neurons</a></p>, date_published=1695945600000, sort_date=1699228800000, tags=[{label=ioAstrocytes, value=ioAstrocytes}, {label=ioGABAergic Neurons, value=ioGABAergic Neurons}], media_contact=<p>Whitehouse et al.<br><em>JoVE Journal of Visualized Experiments&nbsp;</em><br>2023</p> <p>Using <a href="https://www.bit.bio/products/nerve-cells/glutamatergic-neurons-wild-type-io1001" rel="noopener">ioGlutamatergic Neurons</a></p>, listing_button_label=Read more}, {hs_name=Rewiring of the promoter-enhancer interactome and regulatory landscape in glioblastoma orchestrates gene expression underlying neurogliomal synaptic communication, hs_id=178039124124, hs_path=rewiring-of-the-promoter-nature-article, button_label=Read more, button_link=https://www.nature.com/articles/s41467-023-41919-x, type={label=Publication, value=Publication}, thumbnail={alt_text=bitbio-ioGlutamatergic-Neurons, width=1700, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Product%20pages/ioGlutamatergic%20Neurons/bitbio-ioGlutamatergic-Neurons.jpg, height=1300}, year={label=2023, value=2023}, summary=<p>Chakraborty et al<br><em>Nature Communications</em><br>2023</p> <p>Featuring&nbsp;<a href="https://www.bit.bio/products/nerve-cells/glutamatergic-neurons-wild-type-io1001" rel="noopener" target="_blank">ioGlutamatergic Neurons</a></p>, date_published=1697155200000, sort_date=1697155200000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}], media_contact=<p>Chakraborty et al<br><em>Nature Communications</em><br>2023</p> <p>Featuring <a href="https://www.bit.bio/products/nerve-cells/glutamatergic-neurons-wild-type-io1001" rel="noopener" target="_blank">ioGlutamatergic Neurons</a></p>, listing_button_label=Read more}, {hs_name=HNRNPH1 regulates the neuroprotective cold‐shock protein RBM3 expression through poison exon exclusion, hs_id=178039124146, hs_path=hnrnph1-regulates-the-neuroprotective-cold-shock-protein-rbm3-expression-through-poison-exon-exclusion-article, button_label=Read more, button_link=https://www.embopress.org/doi/full/10.15252/embj.2022113168, type={label=Publication, value=Publication}, thumbnail={alt_text=bitbio-ioGlutamatergic-Neurons, width=1700, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Product%20pages/ioGlutamatergic%20Neurons/bitbio-ioGlutamatergic-Neurons.jpg, height=1300}, year={label=2023, value=2023}, summary=<p>Qiaojin Lin et al</p> <p><em>The EMBO Journal</em></p> <p>2023</p> <p>Featuring opti-ox powered hiPSC-derived <a href="https://www.bit.bio/products/nerve-cells/glutamatergic-neurons-wild-type-io1001" rel="noopener" target="_blank">glutamatergic neurons</a> with constitutive expression of Cas9</p>, date_published=1685404800000, sort_date=1685404800000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}], media_contact=<p>Qiaojin Lin et al</p> <p><em>The EMBO Journal</em></p> <p>2023</p> <p>Featuring opti-ox powered hiPSC-derived <a href="https://www.bit.bio/products/nerve-cells/glutamatergic-neurons-wild-type-io1001" rel="noopener" target="_blank">glutamatergic neurons</a> with constitutive expression of Cas9</p>, listing_button_label=Read more}, {hs_name=Schizophrenia risk gene ZNF804A controls ribosome localization and synaptogenesis in developing human neurons, hs_id=178046423390, hs_path=schizophrenia-risk-gene-znf804a-controls-ribosome-localization-and-synaptogenesis-in-developing-human-neurons-article, button_label=Read more, button_link=https://www.biorxiv.org/content/10.1101/2024.02.02.578424v1, type={label=Publication, value=Publication}, thumbnail={alt_text=bitbio-ioGlutamatergic-Neurons, width=1700, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Product%20pages/ioGlutamatergic%20Neurons/bitbio-ioGlutamatergic-Neurons.jpg, height=1300}, year={label=2024, value=2024}, summary=<p><span>Deepak P.</span><span>&nbsp;</span><span>Srivastava, et al</span></p> <p><em>bioRxiv</em></p> <p>2024</p> <p>Featuring <a href="https://www.bit.bio/platform" rel="noopener" target="_blank">opti-ox </a>enabled glutamatergic neurons iPS cell line</p>, date_published=1706832000000, sort_date=1706832000000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}], media_contact=<p><span>Deepak P.</span><span>&nbsp;</span><span>Srivastava, et al</span></p> <p><em>bioRxiv</em></p> <p>2024</p> <p>Featuring <a href="https://www.bit.bio/platform" rel="noopener" target="_blank">opti-ox</a>enabled glutamatergic neurons iPS cell line</p>, listing_button_label=Read more}, {hs_name=Circadian clocks in human cerebral organoids, hs_id=178051600304, hs_path=circadian-clocks-in-human-cerebral-organoids-article, button_label=Read more, button_link=https://www.biorxiv.org/content/10.1101/2024.02.20.580978v1.full, type={label=Publication, value=Publication}, thumbnail={alt_text=Hero image_CRISPR-Ready ioMicroglia, width=1422, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Product%20pages/ioMicroglia/Hero%20image_CRISPR-Ready%20ioMicroglia.png, height=1920}, year={label=2024, value=2024}, summary=<p>Rzechorzek, et al</p> <p><em>bioRxiv</em></p> <p>2024</p> <p>Featuring <a href="https://www.bit.bio/platform" rel="noopener" target="_blank">opti-ox</a>enabled microglia male iPS cell line and opti-ox enabled glutamatergic neurons iPS cell line</p>, date_published=1708473600000, sort_date=1708473600000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioMicroglia, value=ioMicroglia}], media_contact=<p>Rzechorzek, et al</p> <p><em>bioRxiv</em></p> <p>2024</p> <p>Featuring <a href="https://www.bit.bio/platform" rel="noopener" target="_blank">opti-ox</a>enabled microglia male iPS cell line and opti-ox enabled glutamatergic neurons iPS cell line</p>, listing_button_label=Read more}, {hs_name=CRISPR and the Art of Perturbation Screening: Unbiased functional genomic screening meets the best human cellular models, hs_id=161968263475, hs_path=crispr-and-the-art-of-perturbation-screening-unbiased-functional-genomic-screening-meets-the-best-human-cellular-models, button_label=Explore ioCRISPR-Ready Cells, button_link=https://www.bit.bio/iocrispr-ready, type={label=Talk, value=Talk}, thumbnail={alt_text=, width=1318, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/BitBio2022/Resources%20listing/hubdb-thumbs/resources/CRISPR%20and%20the%20Art%20of%20Perturbation%20Screening-min.png, height=1000}, year={label=2021, value=2021}, summary=<p>Kam Dhaliwal <span>| </span>SVP Strategic Alliances | bit.bio</p> <p><br>Talk at ELRIG CRISPR in Drug Discovery</p>, date_published=1706140800000, sort_date=1636070400000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioSkeletal Myocytes, value=ioSkeletal Myocytes}, {label=ioGlutamatergic Neurons HTT 50CAG/WT, value=ioGlutamatergic Neurons HTT 50CAG/WT}, {label=ioSensory Neurons, value=ioSensory Neurons}], media_contact=null, listing_button_label=Watch now}, {hs_name=Consistent and scalable human iPSC-derived cells for in vitro disease modelling and drug discovery, hs_id=161968263476, hs_path=consistent-and-scalable-human-ipsc-derived-cells-for-in-vitro-disease-modelling-and-drug-discovery, button_label=Explore ioCells, button_link=https://www.bit.bio/discover-iocells, type={label=Talk, value=Talk}, thumbnail={alt_text=, width=900, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/DDD_banner_square.jpeg, height=652}, year={label=2020, value=2020}, summary=<p>Kam Dhaliwal <span>|&nbsp;</span> SVP Strategic Alliances | bit.bio<br>Dr Thomas Moreau <span>|</span> Head of Research | bit.bio</p> <p><br>Talk at ELRIG Drug Discovery Digital</p>, date_published=1706400000000, sort_date=1600905600000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioSkeletal Myocytes, value=ioSkeletal Myocytes}, {label=ioGlutamatergic Neurons HTT 50CAG/WT, value=ioGlutamatergic Neurons HTT 50CAG/WT}], media_contact=null, listing_button_label=Watch now}, {hs_name=Precision Cellular Reprogramming for Scalable and Consistent Human Neurodegenerative Disease Models, hs_id=161968263479, hs_path=precision-cellular-reprogramming-for-scalable-and-consistent-human-neurodegenerative-disease-models, button_label=Explore ioDisease Model Cells, button_link=https://www.bit.bio/iodisease-models, type={label=Talk, value=Talk}, thumbnail={alt_text=, width=1860, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Resources/Tech%20Nets%20online%20symposium%20header%20(1).png, height=1260}, year={label=2023, value=2023}, summary=<p>Madeleine Garrett | Field Application Specialist | bit.bio</p>, date_published=1709078400000, sort_date=1681344000000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioGlutamatergic Neurons HTT 50CAG/WT, value=ioGlutamatergic Neurons HTT 50CAG/WT}, {label=ioMicroglia, value=ioMicroglia}, {label=ioGlutamatergic Neurons TDP-43 M337V Het, value=ioGlutamatergic Neurons TDP-43 M337V Het}, {label=ioGlutamatergic Neurons TDP-43 M337V Hom, value=ioGlutamatergic Neurons TDP-43 M337V Hom}, {label=ioGlutamatergic Neurons MAPT P301S/WT, value=ioGlutamatergic Neurons MAPT P301S/WT}, {label=ioGlutamatergic Neurons MAPT P301S/P301S, value=ioGlutamatergic Neurons MAPT P301S/P301S}, {label=ioGlutamatergic Neurons MAPT N279K/WT, value=ioGlutamatergic Neurons MAPT N279K/WT}, {label=ioOligodendrocyte-like cells, value=ioOligodendrocyte-like cells}, {label=ioMotor Neurons, value=ioMotor Neurons}], media_contact=null, listing_button_label=Watch now}, {hs_name=Industrialising Cellular Reprogramming: Leveraging opti-ox Technology to Manufacture Human Cells with Unprecedented Consistency, hs_id=161968263480, hs_path=industrialising-cellular-reprogramming-leveraging-opti-ox-technology-to-manufacture-human-cells-with-unprecedented-consistency, button_label=null, button_link=null, type={label=Talk, value=Talk}, thumbnail={alt_text=, width=1024, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Resources/Resources/video/Squarespace+Thumbnail+Template+-+AM23-01-01-01.png, height=768}, year={label=2023, value=2023}, summary=<p>Innovation showcase talk at ISSCR</p> <p>Marius Wernig MD, PhD | Stanford&nbsp;</p> <p>Mark Kotter, MD, PhD | bit.bio</p>, date_published=1709683200000, sort_date=1688083200000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioGABAergic Neurons, value=ioGABAergic Neurons}, {label=ioSensory Neurons, value=ioSensory Neurons}, {label=CRISPR-Ready ioCells, value=CRISPR-Ready ioCells}], media_contact=<p>V1<br><br>2023<br><br>ISSCR 2023</p>, listing_button_label=Watch now}, {hs_name=ioGlutamatergic Neurons Wild Type and related disease models | User Manual, hs_id=161968263487, hs_path=glutamatergic-neurons, button_label=null, button_link=null, type={label=User manual, value=User manual}, thumbnail={alt_text=bit-bio ioGlutamatergic Neurons Day 14 Beta III Tubulin staining copy, width=1200, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/ioGlutamatergic%20Neurons%20in%20Drug%20Discovery/bit-bio%20ioGlutamatergic%20Neurons%20Day%2014%20Beta%20III%20Tubulin%20staining%20copy.jpeg, height=1200}, year={label=2025, value=2025}, summary=<p>DOC-1289 3.0</p> <p>bit.bio</p> <p>2025<br><br></p>, date_published=1707955200000, sort_date=1713225600000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioGlutamatergic Neurons HTT 50CAG/WT, value=ioGlutamatergic Neurons HTT 50CAG/WT}, {label=ioGlutamatergic Neurons TDP-43 M337V Het, value=ioGlutamatergic Neurons TDP-43 M337V Het}, {label=ioGlutamatergic Neurons TDP-43 M337V Hom, value=ioGlutamatergic Neurons TDP-43 M337V Hom}, {label=ioGlutamatergic Neurons MAPT P301S/WT, value=ioGlutamatergic Neurons MAPT P301S/WT}, {label=ioGlutamatergic Neurons MAPT P301S/P301S, value=ioGlutamatergic Neurons MAPT P301S/P301S}, {label=ioGlutamatergic Neurons MAPT N279K/WT, value=ioGlutamatergic Neurons MAPT N279K/WT}, {label=Product information, value=Product information}], media_contact=<p><span>DOC-1289 3.0</span></p> <p><span>bit.bio</span></p> <p><span>2025</span></p>, listing_button_label=Download}, {hs_name=ioGABAergic Neurons and related disease models | User Manual , hs_id=161968263491, hs_path=gabaergic-neurons, button_label=null, button_link=null, type={label=User manual, value=User manual}, thumbnail={alt_text=, width=1800, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Product%20pages/IoGABAergic%20Neurons/ioGABAergic%20Neurons%20New%20website%202022/Hero-image-GABA-updated-2023.png, height=1800}, year={label=2023, value=2023}, summary=<p><span>V6</span></p> <p><span>bit.bio</span></p> <p><span>2023</span></p>, date_published=1709596800000, sort_date=1688601600000, tags=[{label=ioGABAergic Neurons, value=ioGABAergic Neurons}, {label=Product information, value=Product information}], media_contact=<p>V6</p> <p>bit.bio</p> <p>2023</p>, listing_button_label=Download}, {hs_name=ioMotor Neurons and related disease models | User Manual, hs_id=161968263493, hs_path=motor-neurons, button_label=null, button_link=null, type={label=User manual, value=User manual}, thumbnail={alt_text=, width=2164, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Product%20pages/ioMotor%20Neurons/iomotor_neuron_HERO_ICC_top_CROP2_COMPRESS.png, height=2841}, year={label=2025, value=2025}, summary=V6<br>2025<br>bit.bio, date_published=1741737600000, sort_date=1741737600000, tags=[{label=ioMotor Neurons, value=ioMotor Neurons}, {label=Product information, value=Product information}], media_contact=<p>V6</p> <p>bit.bio</p> <p>2025</p>, listing_button_label=Download}, {hs_name=ioSensory Neurons | User Manual, hs_id=161968263494, hs_path=sensory-neurons, button_label=null, button_link=null, type={label=User manual, value=User manual}, thumbnail={alt_text=, width=980, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/social-suggested-images/www.bit.biohubfsWebsite%20contentProduct%20pagesioSensory%20NeuronsioSensory%20hero%20image-2.png, height=1102}, year={label=2024, value=2024}, summary=V2<br>2024<br>bit.bio, date_published=1710806400000, sort_date=1706054400000, tags=[{label=ioSensory Neurons, value=ioSensory Neurons}, {label=Product information, value=Product information}], media_contact=<p>V2</p> <p>2024</p> <p>bit.bio</p>, listing_button_label=Download}, {hs_name=CRISPRa-Ready ioGlutamatergic Neurons User Manual, hs_id=186090210329, hs_path=crispr-activation-ready-glutamatergic-neurons, button_label=null, button_link=null, type={label=User manual, value=User manual}, thumbnail={alt_text=bit.bio-CRISPRa-ready-ioGlutamatergic-neurons-map2-staining, width=856, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Product%20pages/ioGlutamatergic%20Neurons/CRISPRa-Ready%20ioGlutamatergic%20Neurons/bit.bio-CRISPRa-ready-ioGlutamatergic-neurons-map2-staining.png, height=856}, year={label=2025, value=2025}, summary=V1<br>2025<br>bit.bio, date_published=1739404800000, sort_date=1739404800000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=Product information, value=Product information}, {label=CRISPRa-Ready ioGlutamatergic Neurons, value=crispra-ready_ioglutamatergic_neurons}, {label=CRISPR-Ready ioCells, value=CRISPR-Ready ioCells}], media_contact=V1<br>2025<br>bit.bio, listing_button_label=Download}, {hs_name=CRISPRi-Ready ioGlutamatergic Neurons User Manual, hs_id=186807423031, hs_path=crispri-ready-ioglutamatergic-neurons-user-manual, button_label=null, button_link=null, type={label=User manual, value=User manual}, thumbnail={alt_text=bit.bio-io1098-CRISPRi-ready-glutamatergic-neurons-tubb3-staining, width=856, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Product%20pages/ioGlutamatergic%20Neurons/CRISPRi-Ready%20ioGlutamatergic%20Neurons/bit.bio-io1098-CRISPRi-ready-glutamatergic-neurons-tubb3-staining.png, height=796}, year={label=2025, value=2025}, summary=V1<br>2025<br>bit.bio, date_published=1740960000000, sort_date=1740960000000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=CRISPR-Ready ioCells, value=CRISPR-Ready ioCells}, {label=CRISPR-Ready ioGlutamatergic Neurons, value=CRISPR-Ready ioGlutamatergic Neurons}, {label=Product information, value=Product information}], media_contact=V1<br>2025<br>bit.bio, listing_button_label=Download}, {hs_name=Partnering with Charles River to advance CNS drug discovery with ioGlutamatergic Neurons, hs_id=161968263497, hs_path=in-conversation-with-charles-river-video-part-2, button_label=null, button_link=null, type={label=Video, value=Video}, thumbnail={alt_text=, width=687, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/CRL%20video%20posts/crl%202%20webpage%20image-2.png, height=476}, year={label=2021, value=2021}, summary=<p>Dr Marijn Vlaming | Head of Biology, et al.</p> <p>Charles River &amp; bit.bio</p>, date_published=1705017600000, sort_date=1637107200000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioGlutamatergic Neurons TDP-43 M337V Het, value=ioGlutamatergic Neurons TDP-43 M337V Het}, {label=ioGlutamatergic Neurons TDP-43 M337V Hom, value=ioGlutamatergic Neurons TDP-43 M337V Hom}], media_contact=null, listing_button_label=Watch }, {hs_name=In Conversation with Charles River, hs_id=161968263498, hs_path=in-conversation-with-charles-river-video, button_label=Discover our ioCells portfolio, button_link=/discover-iocells, type={label=Video, value=Video}, thumbnail={alt_text=, width=834, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/CRL%20video%20posts/CRL%20video%20%231%20card%20for%20webpage%20(thinner%20gradient%20line)-1.png, height=590}, year={label=2021, value=2021}, summary=<p>Dr Marijn Vlaming <span>|</span> Head of Biology<br>Charles River</p>, date_published=1705363200000, sort_date=1636675200000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}], media_contact=null, listing_button_label=Watch}, {hs_name=Accelerating in vitro target and drug discovery using reprogrammed glutamatergic neurons, hs_id=161968263499, hs_path=dr-shushant-jain-video-2020, button_label=null, button_link=null, type={label=Video, value=Video}, thumbnail={alt_text=, width=1318, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/BitBio2022/Resources/Resource-thumbs/Accelerating%20in%20vitro%20target%20and%20drug%20discovery%20using%20reprogrammed%20glutamatergic%20neurons-min.png, height=1000}, year={label=2020, value=2020}, summary=<p>Dr Shushant Jain <span>|</span> Group Leader In Vitro Biology | Charles River</p> <p>Interview at SLAS</p>, date_published=1706832000000, sort_date=1595635200000, tags=[{label=ioSensory Neurons, value=ioSensory Neurons}], media_contact=null, listing_button_label=Watch}, {hs_name=MaxWell Summit 2024_Poster Presentation with Luke Foulser_ioMotor Neurons, hs_id=165873178459, hs_path=presentation-at-maxwell-summit-2024, button_label=null, button_link=null, type={label=Video, value=Video}, thumbnail={alt_text=Luke pointing at ioMotor Neurons poster at MaxWell Summit 2024_cropped, width=2152, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Emails/Newsletter/Luke%20pointing%20at%20ioMotor%20Neurons%20poster%20at%20MaxWell%20Summit%202024_cropped.png, height=1211}, year={label=2024, value=2024}, summary=<p>Luke Foulser | Scientist | bit.bio</p>, date_published=1714435200000, sort_date=1714435200000, tags=[{label=ioMotor Neurons, value=ioMotor Neurons}], media_contact=null, listing_button_label=Watch }, {hs_name=Culturing Glutamatergic Neurons | How-to Video, hs_id=161966111374, hs_path=how-to-culture-ioglutamatergic-neurons, button_label=Download the user manual, button_link=/resources/ioglutamatergic-neurons-user-manual, type={label=Video tutorial, value=Video tutorial}, thumbnail={alt_text=, width=1318, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/BitBio2022/Resources%20listing/hubdb-thumbs/resources/How%20to%20prepare%20tissue%20culture%20vessels%20with%20PDL-Geltrex-min.png, height=1000}, year={label=2021, value=2021}, summary=<p>Dr Kaiser Karim <span>|</span> Scientist<br>bit.bio</p>, date_published=1705104000000, sort_date=1637020800000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioGlutamatergic Neurons TDP-43 M337V Het, value=ioGlutamatergic Neurons TDP-43 M337V Het}, {label=ioGlutamatergic Neurons TDP-43 M337V Hom, value=ioGlutamatergic Neurons TDP-43 M337V Hom}], media_contact=null, listing_button_label=Watch now}, {hs_name=Preparing Culture Vessels for Glutamatergic Neurons | How-to Video, hs_id=161966111375, hs_path=how-to-prepare-tissue-culture-vessels-with-pdl-geltrex, button_label=Watch the next video, button_link=/resources/how-to-culture-ioglutamatergic-neurons, type={label=Video tutorial, value=Video tutorial}, thumbnail={alt_text=, width=1318, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/BitBio2022/Resources%20listing/hubdb-thumbs/resources/How%20to%20culture%20ioGlutamatergic%20Neurons-min.png, height=1000}, year={label=2021, value=2021}, summary=<p>Dr Kaiser Karim <span>|</span> Scientist<br>bit.bio</p>, date_published=1705190400000, sort_date=1636934400000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioGlutamatergic Neurons TDP-43 M337V Het, value=ioGlutamatergic Neurons TDP-43 M337V Het}, {label=ioGlutamatergic Neurons TDP-43 M337V Hom, value=ioGlutamatergic Neurons TDP-43 M337V Hom}], media_contact=null, listing_button_label=Watch now}, {hs_name=Modelling neurodevelopment | Investigating the impact of maternal immune activation on neurodevelopment using human iPSC-derived cells, hs_id=161968263519, hs_path=modelling-neurodevelopment-webinar-2022, button_label=Explore ioGlutamatergic Neurons, button_link=https://www.bit.bio/products/nerve-cells/glutamatergic-neurons-wild-type-io1001, type={label=Webinar, value=Webinar}, thumbnail={alt_text=, width=1200, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/BitBio2022/product-page/Colour%20webinar%20with%2060x%20Map2-com.jpg, height=732}, year={label=2022, value=2022}, summary=<p><span>Dr Deepak Srivastava | King’s College London<br><br></span><span></span></p>, date_published=1707436800000, sort_date=1649376000000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioGABAergic Neurons, value=ioGABAergic Neurons}], media_contact=null, listing_button_label=Watch now}, {hs_name=Modelling human neurodegenerative diseases in research & drug discovery, hs_id=161968263520, hs_path=modelling-human-neurodegenerative-diseases-in-research-drug-discovery, button_label=Explore ioDisease Model Cells, button_link=https://www.bit.bio/iodisease-models, type={label=Webinar, value=Webinar}, thumbnail={alt_text=, width=1200, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/BitBio2022/product-page/Colour%20webinar%20with%20it-bio%20ioGlutamatergic%20Neurons_VGLUT2(G)_MAP2(R)_Tubb3(B)_Hoechst(B)_20x_merge-comp.jpg, height=717}, year={label=2022, value=2022}, summary=<p><span>Dr Mariangela Iovino | Group Leader | Charles River</span></p> <p><span>Dr Tony Oosterveen | Senior Scientist | bit.bio</span></p>, date_published=1707523200000, sort_date=1649116800000, tags=[{label=ioGABAergic Neurons, value=ioGABAergic Neurons}, {label=Product information, value=Product information}, {label=ioGlutamatergic Neurons HTT 50CAG/WT, value=ioGlutamatergic Neurons HTT 50CAG/WT}, {label=ioMicroglia, value=ioMicroglia}, {label=ioGlutamatergic Neurons TDP-43 M337V Het, value=ioGlutamatergic Neurons TDP-43 M337V Het}, {label=ioGlutamatergic Neurons TDP-43 M337V Hom, value=ioGlutamatergic Neurons TDP-43 M337V Hom}, {label=ioSensory Neurons, value=ioSensory Neurons}], media_contact=<p>&nbsp;</p> <p>&nbsp;</p>, listing_button_label=Watch now}, {hs_name=Rethinking Developmental Biology With Cellular Reprogramming, hs_id=161968263524, hs_path=rethinking-developmental-biology-with-cellular-reprogramming, button_label=Explore ioCells, button_link=https://www.bit.bio/discover-iocells, type={label=Webinar, value=Webinar}, thumbnail={alt_text=, width=1860, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Upcoming%20Webinars/Tech%20Nets%202023/bit.bio_ioGlutamatergic%20Neurons_20xMAP2(red)Hoescht(blue)_day12v2.png, height=1260}, year={label=2023, value=2023}, summary=<p>Mark Kotter | CEO and founder | bit.bio</p> <p>Marius Wernig | Professor Departments of Pathology and Chemical and Systems Biology |&nbsp; Stanford University</p>, date_published=1709164800000, sort_date=1681776000000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioGABAergic Neurons, value=ioGABAergic Neurons}, {label=ioMicroglia, value=ioMicroglia}, {label=Cell therapy, value=Cell therapy}, {label=ioSensory Neurons, value=ioSensory Neurons}, {label=ioOligodendrocyte-like cells, value=ioOligodendrocyte-like cells}], media_contact=null, listing_button_label=Watch now}, {hs_name=Addressing the Reproducibility Crisis | Driving Genome-Wide Consistency in Cellular Reprogramming, hs_id=161968263525, hs_path=addressing-the-reproducibility-crisis-driving-genome-wide-consistency-in-cellular-reprogramming, button_label=Explore ioCells, button_link=https://www.bit.bio/discover-iocells, type={label=Webinar, value=Webinar}, thumbnail={alt_text=, width=1860, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Upcoming%20Webinars/Tech%20Nets%2019th%20July%202023/bit.bio_ioGlutamatergic%20Neurons_60xMAP2(red)Hoescht(blue)TUBB3(blue)_day4.jpg, height=1260}, year={label=2023, value=2023}, summary=<p>Dr Ania Wilczynska | Head of Computational Genomics | Non-Clinical | bit.bio</p>, date_published=1709769600000, sort_date=1689724800000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioGABAergic Neurons, value=ioGABAergic Neurons}, {label=ioSensory Neurons, value=ioSensory Neurons}, {label=CRISPR-Ready ioGlutamatergic Neurons, value=CRISPR-Ready ioGlutamatergic Neurons}], media_contact=null, listing_button_label=Watch now}, {hs_name=Mastering Cell Identity In A Dish: The Power Of Cellular Reprogramming, hs_id=161968263526, hs_path=mastering-cell-identity-in-a-dish-the-power-of-cellular-reprogramming, button_label=null, button_link=null, type={label=Webinar, value=Webinar}, thumbnail={alt_text=, width=3926, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Upcoming%20Webinars/GEN%2023rd%20June%202023/io1013S-ioGlutamatergic-Neurons-PRKN-R275W-heterozygous-ICC-DAPI-MAP2.jpeg, height=1629}, year={label=2023, value=2023}, summary=<p>Prof Roger Pedersen | Adjunct Professor and Senior Research Scientist at Stanford University&nbsp;</p> <p>Dr Thomas Moreau | Director of Cell Biology Research | bit.bio</p>, date_published=1709856000000, sort_date=1686700800000, tags=[{label=ioGABAergic Neurons, value=ioGABAergic Neurons}, {label=ioMicroglia, value=ioMicroglia}, {label=ioSensory Neurons, value=ioSensory Neurons}, {label=ioMotor Neurons, value=ioMotor Neurons}], media_contact=null, listing_button_label=Watch now}, {hs_name=Running Large-Scale CRISPR Screens in Human Neurons, hs_id=161968263528, hs_path=running-large-scale-crispr-screens-in-human-neurons, button_label=null, button_link=null, type={label=Webinar, value=Webinar}, thumbnail={alt_text=, width=1200, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Emails/Header%20images/Header%20Images%20-%20ICC%20only/Running%20Large-Scale%20CRISPR%20Screens%20in%20Human%20Neurons_email%20header.png, height=678}, year={label=2023, value=2023}, summary=<p>Emmanouil Metzakopian | Vice President, Research and Development | bit.bio</p> <p>Javier Conde-Vancells | Director Product Management | bit.bio</p>, date_published=1710460800000, sort_date=1700524800000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=CRISPR-Ready ioCells, value=CRISPR-Ready ioCells}, {label=CRISPR-Ready ioGlutamatergic Neurons, value=CRISPR-Ready ioGlutamatergic Neurons}, {label=CRISPR-Ready ioMicroglia, value=CRISPR-Ready ioMicroglia}], media_contact=null, listing_button_label=Watch now}, {hs_name=Empowering motor neuron disease research and drug discovery with a new class of functional, reproducible hiPSC-derived motor neurons, hs_id=161968263529, hs_path=empowering-motor-neuron-disease-research-and-drug-discovery-with-a-new-class-of-functional-reproducible-hipsc-derived-motor-neurons, button_label=null, button_link=null, type={label=Webinar, value=Webinar}, thumbnail={alt_text=, width=2040, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Upcoming%20Webinars/Select%20Science%20Jan%202024%20-%20Empowering%20MND%20research/ioMotor%20Neuron%20Hero%20image%20for%20Webinar%20(1).png, height=1380}, year={label=2024, value=2024}, summary=<p>Tom Brown | Senior Product Manager | bit.bio</p> Marcos Herrera Vaquero, PhD | Senior Scientist | bit.bio, date_published=1710979200000, sort_date=1707696000000, tags=[{label=ioMotor Neurons, value=ioMotor Neurons}], media_contact=null, listing_button_label=Watch now}, {hs_name=Uncovering the Glioma Microenvironment With In Vitro Neuronal Models, hs_id=166831992936, hs_path=uncovering-the-glioma-microenvironment-with-in-vitro-neuronal-models, button_label=null, button_link=null, type={label=Webinar, value=Webinar}, thumbnail={alt_text=Hero image V4, width=1200, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Product%20pages/IoGABAergic%20Neurons/ioGABAergic%20Neurons%20New%20website%202022/Hero%20image%20V4.png, height=2000}, year={label=2024, value=2024}, summary=<p>Dr Brian Gill, MD | Assistant Professor of Neurological Surgery| Columbia University Irving Medical Center<br><br>Dr Tony Oosterveen | Principal Scientist and CNS Lead, Neurobiology | bit.bio</p> <p>&nbsp;</p>, date_published=1715212800000, sort_date=1715212800000, tags=[{label=ioGABAergic Neurons, value=ioGABAergic Neurons}, {label=ioAstrocytes, value=ioAstrocytes}], media_contact=null, listing_button_label=Watch now}, {hs_name=Human iPSC-Based Models of Glial Cells for Studying Neurodegenerative Disease, hs_id=183096620633, hs_path=human-ipsc-based-models-of-glial-cells-for-studying-neurodegenerative-disease, button_label=null, button_link=null, type={label=Webinar, value=Webinar}, thumbnail={alt_text=bitbio-oligodendrocyte-like-cells-O4-MBP-immunocytochemistry, width=1000, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Product%20pages/ioOligodendrocyte-like%20cells/bitbio-oligodendrocyte-like-cells-O4-MBP-immunocytochemistry.jpg, height=1350}, year={label=2024, value=2024}, summary=Valentina Fossati, PhD | Senior Research Investigator | The New York Stem Cell Foundation<br><br>Inês Ferreira | Senior Product Manager | bit.bio, date_published=1732233600000, sort_date=1732233600000, tags=[{label=ioGlutamatergic Neurons, value=ioGlutamatergic Neurons}, {label=ioOligodendrocyte-like cells, value=ioOligodendrocyte-like cells}], media_contact=null, listing_button_label=Watch now}, {hs_name=Harnessing AI-guided visual biology to discover drug targets for neurodegenerative disease, hs_id=189003500550, hs_path=harnessing-ai-guided-visual-biology-to-discover-drug-targets-for-neurodegenerative-disease, button_label=null, button_link=null, type={label=Webinar, value=Webinar}, thumbnail={alt_text=ioMotor Neuron Hero image for Webinar (1), width=2040, url=https://14527135.fs1.hubspotusercontent-na1.net/hubfs/14527135/Website%20content/Upcoming%20Webinars/Select%20Science%20Jan%202024%20-%20Empowering%20MND%20research/ioMotor%20Neuron%20Hero%20image%20for%20Webinar%20(1).png, height=1380}, year={label=2025, value=2025}, summary=<p>Ben Bar-Sadeh, PhD | Senior Scientist | Anima Biotech<br><br></p> <p>Tom Brown | Senior Product Manager | bit.bio</p>, date_published=1744243200000, sort_date=1744243200000, tags=[{label=ioMotor Neurons, value=ioMotor Neurons}], media_contact=null, listing_button_label=Watch now}])

Webinar

Harnessing AI-guided visual biology to discover drug targets for neurodegenerative disease

Ben Bar-Sadeh, PhD | Senior Scientist | Anima Biotech

Tom Brown | Senior Product Manager | bit.bio

Watch now

User manual

ioMotor Neurons and related disease models | User Manual

V6
2025
bit.bio

Download

User manual

CRISPRi-Ready ioGlutamatergic Neurons User Manual

V1
2025
bit.bio

Download

User manual

CRISPRa-Ready ioGlutamatergic Neurons User Manual

V1
2025
bit.bio

Download

Webinar

Human iPSC-Based Models of Glial Cells for Studying Neurodegenerative Disease

Valentina Fossati, PhD | Senior Research Investigator | The New York Stem Cell Foundation

Inês Ferreira | Senior Product Manager | bit.bio

Watch now

Application note

Characterisation of ioSensory Neurons on the Patchliner

V1
A Obergrussberger et al, 2024.
Nanion

Download

Application note

Producing 3D Neuronal Microtissues for Preclinical Drug Screening using ioGlutamatergic Neurons

V1
2024
bit.bio
Inventia

Download

Application note

Sartorius application note - Advanced in vitro Modeling of Human iPSC-derived Neuronal Mono- and Co-cultures with Microglia

Trigg et al.,
Sartorius
2024

Download

Webinar

Uncovering the Glioma Microenvironment With In Vitro Neuronal Models

Dr Brian Gill, MD | Assistant Professor of Neurological Surgery| Columbia University Irving Medical Center

Dr Tony Oosterveen | Principal Scientist and CNS Lead, Neurobiology | bit.bio

 

Watch now

Video

MaxWell Summit 2024_Poster Presentation with Luke Foulser_ioMotor Neurons

Luke Foulser | Scientist | bit.bio

Watch

Poster

Rapid and consistent generation of functional motor neurons from reprogrammed human iPSCs using opti-ox technology

Foulser, et al 
bit.bio
2024

Download

Brochure

ioMotor Neurons

bit.bio

Download

Brochure

ioSensory Neurons

bit.bio

Download

Brochure

ioGlutamatergic Neurons

bit.bio

Download

User manual

ioGlutamatergic Neurons Wild Type and related disease models | User Manual

DOC-1289 3.0

bit.bio

2025

Download

Publication

Circadian clocks in human cerebral organoids

Rzechorzek, et al

bioRxiv

2024

Featuring opti-ox enabled microglia male iPS cell line and opti-ox enabled glutamatergic neurons iPS cell line

Read more

Poster

Generation and characterisation of a panel of human iPSC-derived neurons and microglia carrying early and late onset relevant mutations for Alzheimer’s disease

Smith, et al. 
bit.bio
2024

Download

Webinar

Empowering motor neuron disease research and drug discovery with a new class of functional, reproducible hiPSC-derived motor neurons

Tom Brown | Senior Product Manager | bit.bio

Marcos Herrera Vaquero, PhD | Senior Scientist | bit.bio

Watch now

Publication

Schizophrenia risk gene ZNF804A controls ribosome localization and synaptogenesis in developing human neurons

Deepak P. Srivastava, et al

bioRxiv

2024

Featuring opti-ox enabled glutamatergic neurons iPS cell line

Read more

User manual

ioSensory Neurons | User Manual

V2
2024
bit.bio

Download

References

1. Pereira I, Lopez-Martinez MJ, Samitier J. (2023) Advances in current in vitro models on neurodegenerative diseases. Front. Bioeng. Biotechnol. doi: 10.3389/fbioe.2023.1260397.

Related pages

Discover ioCells Learn about our range of human iPSC-derived cells for research and drug discovery

Resources Explore our latest scientific insights, webinars, blogs and videos

Our platform Discover the cell coding platform that powers our ioCells