Human iPSC-derived neurons

Consistent, defined and scalable human iPSC-derived neurons for neurodegeneration, neurophysiology, and neurodevelopmental research

Nerve cells, also known as neurons are the fundamental units of the brain and nervous system, responsible for receiving and transmitting information throughout the body. Rich with multiple neuronal cell types and varied glial cells, neural tissue has historically been difficult to model in vitro [1]. Such modelling challenges greatly slow our progress in understanding and treating neurodegenerative disease. Fortunately, this is changing with recent advances in induced pluripotent stem cell (iPSC) technology. 

bit.bio’s deterministic cell programming technology (known as opti-ox™) enables the rapid conversion of entire cultures of stem cells into a precise cell identity with unprecedented consistency. The rapid gain of functionality of bit.bio’s human nerve cells empower researchers to build the types of physiologically relevant in vitro models needed to drive research into neurodegenerative disease and neuropsychiatric disorders, and the data-backed lot-to-lot consistency enables standardisation across assays used in early stages of drug discovery, from target identification to clinical translation.

Additionally, the development of CRISPR-Ready neurons makes it possible to perform functional genomic screening in human iPSC-derived neurons, opening the door to more efficient and physiologically relevant target identification and validation studies. Unlike primary neurons that often lack suitable controls, our range of ioCells includes disease models with engineered disease-specific mutations and genetically matched controls. Having access to defined, human iPSC-derived neurons that emulate neurodegenerative disease will help accelerate progress in understanding and ultimately treating these devastating diseases.  

Elevate your research with bit.bio’s human iPSC-derived neurons, from CRISPR-Ready glutamatergic neurons to ALS-specific motor neurons.

ioWild Type Cells

ioGABAergic Neurons ioWild Type Cells
ioGABAergic Neurons cat no | io1003
ioGlutamatergic Neurons ioWild Type Cells
ioGlutamatergic Neurons cat no | io1001
ioSensory Neurons ioWild Type Cells
ioSensory Neurons cat no | io1024
ioMotor Neurons ioWild Type Cells
ioMotor Neurons cat no | io1027

Engineered to meet your workflow with our toolkit of ioDisease Model Cells and CRISPR-Ready ioCells

CRISPRko-Ready ioGlutamatergic Neurons CRISPR-Ready ioCells
CRISPRko-Ready ioGlutamatergic Neurons cat no | io1090
ioGABAergic Neurons APP V717I/WT ioDisease Model Cells
ioGABAergic Neurons APP V717I/WT cat no | io1085
ioGABAergic Neurons APP V717I/V717I ioDisease Model Cells
ioGABAergic Neurons APP V717I/V717I cat no | io1082
ioMotor Neurons TDP-43 M337V/WT ioDisease Model Cells
ioMotor Neurons TDP-43 M337V/WT cat no | io1050
ioMotor Neurons TDP-43 M337V/M337V ioDisease Model Cells
ioMotor Neurons TDP-43 M337V/M337V cat no | io1046
ioGlutamatergic Neurons HTT 50CAG/WT ioDisease Model Cells
ioGlutamatergic Neurons HTT 50CAG/WT cat no | ioEA1004
ioMotor Neurons SOD-1 G93A/WT ioDisease Model Cells
ioMotor Neurons SOD-1 G93A/WT cat no | io1042
ioMotor Neurons SOD-1 G93A/G93A ioDisease Model Cells
ioMotor Neurons SOD-1 G93A/G93A cat no | io1041
ioMotor Neurons FUS P525L/WT ioDisease Model Cells
ioMotor Neurons FUS P525L/WT cat no | io1055
ioMotor Neurons FUS P525L/P525L ioDisease Model Cells
ioMotor Neurons FUS P525L/P525L cat no | io1052
ioMotor Neurons TDP-43 A382T/WT ioDisease Model Cells
ioMotor Neurons TDP-43 A382T/WT cat no | io6019
ioMotor Neurons TDP-43 N352S/WT ioDisease Model Cells
ioMotor Neurons TDP-43 N352S/WT cat no | io6017
ioGlutamatergic Neurons TDP-43 M337V/M337V ioDisease Model Cells
ioGlutamatergic Neurons TDP-43 M337V/M337V cat no | ioEA1005
ioGlutamatergic Neurons TDP-43 M337V/WT ioDisease Model Cells
ioGlutamatergic Neurons TDP-43 M337V/WT cat no | ioEA1006
ioGlutamatergic Neurons PRKN R275W/WT ioDisease Model Cells
ioGlutamatergic Neurons PRKN R275W/WT cat no | io1013
ioGlutamatergic Neurons PRKN R275W/R275W ioDisease Model Cells
ioGlutamatergic Neurons PRKN R275W/R275W cat no | io1020
ioGlutamatergic Neurons SNCA A53T/A53T ioDisease Model Cells
ioGlutamatergic Neurons SNCA A53T/A53T cat no | io1088
ioGlutamatergic Neurons SNCA A53T/WT ioDisease Model Cells
ioGlutamatergic Neurons SNCA A53T/WT cat no | io6005
ioGlutamatergic Neurons PSEN1 M146L/M146L ioDisease Model Cells
ioGlutamatergic Neurons PSEN1 M146L/M146L cat no | io1069
ioGlutamatergic Neurons PSEN1 M146L/WT ioDisease Model Cells
ioGlutamatergic Neurons PSEN1 M146L/WT cat no | io1072
ioGlutamatergic Neurons APP V717I/WT ioDisease Model Cells
ioGlutamatergic Neurons APP V717I/WT cat no | io1067
ioGABAergic Neurons APP V717I/V717I ioDisease Model Cells
ioGABAergic Neurons APP V717I/V717I cat no | io1082
ioGlutamatergic Neurons APP KM670/671NL/WT ioDisease Model Cells
ioGlutamatergic Neurons APP KM670/671NL/WT cat no | io1061
ioGlutamatergic Neurons APP V717I/V717I ioDisease Model Cells
ioGlutamatergic Neurons APP V717I/V717I cat no | io1063
ioGlutamatergic Neurons GBA null/R159W ioDisease Model Cells
ioGlutamatergic Neurons GBA null/R159W cat no | io1007
CRISPRa-Ready ioGlutamatergic Neurons CRISPR-Ready ioCells
CRISPRa-Ready ioGlutamatergic Neurons cat no | io1099
CRISPRi-Ready ioGlutamatergic Neurons CRISPR-Ready ioCells
CRISPRi-Ready ioGlutamatergic Neurons cat no | io1098

Producing 3D Neuronal Microtissues for Preclinical Drug Screening using ioGlutamatergic Neurons

Dive into this application note, to discover how ioGlutamatergic Neurons and iPSC-derived astrocytes have been used in 3D microtissues, to build a powerful model system for medium- to high-throughput drug screening and more productive preclinical drug development.

Download application note
App note - inventia

Product resources

CRISPRko-Ready ioMotor Neurons user manual | bit.bio User manual
CRISPRko-Ready ioMotor Neurons user manual | bit.bio

DOC-3073 V2
2025
bit.bio

Download
Modelling neurodevelopment | Investigating the impact of maternal immune activation on neurodevelopment using human iPSC-derived cells | bit.bio Webinar
Modelling neurodevelopment | Investigating the impact of maternal immune activation on neurodevelopment using human iPSC-derived cells | bit.bio

Dr Deepak Srivastava | King’s College London

Watch now
Rethinking Developmental Biology With Cellular Reprogramming | bit.bio Webinar
Rethinking Developmental Biology With Cellular Reprogramming | bit.bio

Mark Kotter | CEO and founder | bit.bio

Marius Wernig | Professor Departments of Pathology and Chemical and Systems Biology |  Stanford University

Watch now
Addressing the Reproducibility Crisis | Driving Genome-Wide Consistency in Cellular Reprogramming | bit.bio Webinar
Addressing the Reproducibility Crisis | Driving Genome-Wide Consistency in Cellular Reprogramming | bit.bio

Dr Ania Wilczynska | Head of Computational Genomics | Non-Clinical | bit.bio

Watch now
Mastering Cell Identity In A Dish: The Power Of Cellular Reprogramming | bit.bio Webinar
Mastering Cell Identity In A Dish: The Power Of Cellular Reprogramming | bit.bio

Prof Roger Pedersen | Adjunct Professor and Senior Research Scientist at Stanford University 

Dr Thomas Moreau | Director of Cell Biology Research | bit.bio

Watch now
Running Large-Scale CRISPR Screens in Human Neurons | bit.bio Webinar
Running Large-Scale CRISPR Screens in Human Neurons | bit.bio

Emmanouil Metzakopian | Vice President, Research and Development | bit.bio

Javier Conde-Vancells | Director Product Management | bit.bio

Watch now
Empowering motor neuron disease research and drug discovery with a new class of functional, reproducible hiPSC-derived motor neurons | bit.bio Webinar
Empowering motor neuron disease research and drug discovery with a new class of functional, reproducible hiPSC-derived motor neurons | bit.bio

Tom Brown | Senior Product Manager | bit.bio

Marcos Herrera Vaquero, PhD | Senior Scientist | bit.bio
Watch now
Human iPSC-Based Models of Glial Cells for Studying Neurodegenerative Disease | bit.bio Webinar
Human iPSC-Based Models of Glial Cells for Studying Neurodegenerative Disease | bit.bio
Valentina Fossati, PhD | Senior Research Investigator | The New York Stem Cell Foundation

Inês Ferreira | Senior Product Manager | bit.bio
Watch now
Harnessing AI-guided visual biology to discover drug targets for neurodegenerative disease | bit.bio Webinar
Harnessing AI-guided visual biology to discover drug targets for neurodegenerative disease | bit.bio

Ben Bar-Sadeh, PhD | Senior Scientist | Anima Biotech

Tom Brown | Senior Product Manager | bit.bio

Watch now

References

1. Pereira I, Lopez-Martinez MJ, Samitier J. (2023) Advances in current in vitro models on neurodegenerative diseases. Front. Bioeng. Biotechnol. doi: 10.3389/fbioe.2023.1260397.

Related pages

Glial cells Explore our range of hiPSC-derived glial cells
Muscle cells Explore our range of hiPSC-derived muscle cells
Contact us Talk to us about how our technology could support your cell therapies