Harnessing CRISPR-Ready ioCells as functional genomics tools for drug target identification and validation

CRISPRko-Ready ioCells have been built for scientists looking to generate high-efficiency gene knockouts in physiologically relevant human cells. Based on our opti-ox powered ioWild Type Cells, these cells offer users a well-defined and characterised human model with high lot-to-lot consistency and simple protocols for handling and culturing.

Each model can be used with an optimised protocol for guide RNA (sgRNA) delivery that helps maximise knockout efficiency. Scientists can scale from single gene knockouts to pooled or arrayed CRISPR screens for applications including functional genomics, disease model generation, drug target identification and fundamental human biology research.