Human iPSC-derived glial cells

Consistent, defined and scalable human iPSC-derived glial cell types for neurodegenerative disease research

Glial cells include astrocytes, microglia, oligodendrocytes, and associated precursor cells that enable the brain to function. Once known as nervenkitt (a German word meaning “nerve glue”), glial cells are the “glue” that holds the nervous system together by facilitating neuronal signalling, enabling tissue plasticity, providing neuronal support and axonal integrity, metabolism, and protecting neurons from would-be pathogens [1,2]. 

In recent years, a greater appreciation for the role of glial cells in neuronal homeostasis has helped expose potential therapeutic targets in neurodegenerative disease. Glial cells play a complex, enigmatic role in the development and progression of Alzheimer’s disease, Parkinson’s disease, and others. Many research projects are now focussing on understanding the therapeutic potential of targeting glial cells in neurodegenerative disease [2]. 

With access to a consistent and defined source of human glial cell types, researchers can build the complex, physiologically relevant glial cell culture models that are sorely needed in for drug discovery. Whether co-cultured with neurons, as part of a multi-cellular glial-neuronal culture, or used to build three-dimensional tissue models, ioCells are well suited for tissue and neurodegenerative disease modelling; for drug target identification and validation; as well as drug screening among many other uses. 

Take your research to the next level with our ioCells below.

ioWild Type Cells

ioAstrocytes ioWild Type Cells
ioAstrocytes cat no | ioEA1093
ioMicroglia | Female ioWild Type Cells
ioMicroglia | Female cat no | io1029
ioMicroglia | Male ioWild Type Cells
ioMicroglia | Male cat no | io1021
ioOligodendrocyte-like cells ioWild Type Cells
ioOligodendrocyte-like cells cat no | io1028

Engineered to meet your workflow with our toolkit of ioDisease Model Cells,  ioTracker Cells and CRISPR-Ready ioCells

New! GFP ioMicroglia | Male ioTracker Cells
New! GFP ioMicroglia | Male cat no | io1096
CRISPRko-Ready ioMicroglia Male CRISPR-Ready ioCells
CRISPRko-Ready ioMicroglia Male cat no | io1094
ioMicroglia TREM2 R47H/WT ioDisease Model Cells
ioMicroglia TREM2 R47H/WT cat no | io1038
ioMicroglia TREM2 R47H/R47H ioDisease Model Cells
ioMicroglia TREM2 R47H/R47H cat no | io1035
ioMicroglia APOE 4/3 C112R/WT ioDisease Model Cells
ioMicroglia APOE 4/3 C112R/WT cat no | io1033
ioMicroglia APOE 4/4 C112R/C112R ioDisease Model Cells
ioMicroglia APOE 4/4 C112R/C112R cat no | io1032

Human iPSC-based models of glial cells for studying neurodegenerative disease

Explore the implication of glial cells in neurodegenerative diseases in this webinar featuring Dr Valentina Fossati, Senior Research Investigator, The New York Stem Cell Foundation. 

Watch webinar
bitbio-oligodendrocyte-like-cells-O4-MBP-immunocytochemistry

Product resources

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Human iPSC-Based Models of Glial Cells for Studying Neurodegenerative Disease Webinar
Human iPSC-Based Models of Glial Cells for Studying Neurodegenerative Disease
Valentina Fossati, PhD | Senior Research Investigator | The New York Stem Cell Foundation

Inês Ferreira | Senior Product Manager | bit.bio
Watch now
Exploring the critical roles of astrocytes in health and disease Webinar
Exploring the critical roles of astrocytes in health and disease
Jeremy Krohn | PhD candidate | German Center for Neurodegenerative Diseases (DZNE) Charité Medical Neuroscience Graduate Program

Tom Brown | Senior Product Manager | bit.bio
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Producing 3D Neuronal Microtissues for Preclinical Drug Screening using ioGlutamatergic Neurons Application note
Producing 3D Neuronal Microtissues for Preclinical Drug Screening using ioGlutamatergic Neurons
V1
2024
bit.bio
Inventia
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ioAstrocytes | User Manual User manual
ioAstrocytes | User Manual

V6

2024

bit.bio

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Uncovering the Glioma Microenvironment With In Vitro Neuronal Models Webinar
Uncovering the Glioma Microenvironment With In Vitro Neuronal Models

Dr Brian Gill, MD | Assistant Professor of Neurological Surgery| Columbia University Irving Medical Center

Dr Tony Oosterveen | Principal Scientist and CNS Lead, Neurobiology | bit.bio

 

Watch now
ioOligodendrocyte-like cells Brochure
ioOligodendrocyte-like cells
bit.bio
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ioGlutamatergic Neurons Brochure
ioGlutamatergic Neurons

bit.bio

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3D bioprinting of iPSC neuron-astrocyte coculture Publication
3D bioprinting of iPSC neuron-astrocyte coculture

Whitehouse, et al
JoVE Journal of Visualized Experiments 
2023

Using ioGlutamatergic Neurons

Read more
ioOligodendrocyte-like cells | User Manual User manual
ioOligodendrocyte-like cells | User Manual

V2

bit.bio

2024

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Rethinking Developmental Biology With Cellular Reprogramming Webinar
Rethinking Developmental Biology With Cellular Reprogramming

Mark Kotter | CEO and founder | bit.bio

Marius Wernig | Professor Departments of Pathology and Chemical and Systems Biology |  Stanford University

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Precision Cellular Reprogramming for Scalable and Consistent Human Neurodegenerative Disease Models Talk
Precision Cellular Reprogramming for Scalable and Consistent Human Neurodegenerative Disease Models

Madeleine Garrett | Field Application Specialist | bit.bio

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Alzheimer’s Disease Pathogenesis: Emerging Role of Microglia Webinar
Alzheimer’s Disease Pathogenesis: Emerging Role of Microglia

Dr Matthias Pawlowski | Head, Dementia-Sensitive Hospital | University of Münster

Dr Malathi Raman | Senior Product Manager | bit.bio

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Cellular reprogramming to enable the precise and scalable manufacturing of human cells for therapeutic applications Talk
Cellular reprogramming to enable the precise and scalable manufacturing of human cells for therapeutic applications

Dr Alex Davenport | Senior Scientist | bit.bio

Talk at ELRIG Cell & Gene Therapy

2021

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Reprogramming the stem cell for a new generation of cures Publication
Reprogramming the stem cell for a new generation of cures

Davenport A, Frolov T & Kotter M

Drug Discovery World

2020

 

 

Read more

References

1. Jäkel S, Dimou L. (2017) Glial Cells and Their Function in the Adult Brain: A Journey through the History of Their Ablation. Front Cell Neurosci. 2017 Feb 13;11:24. doi: 10.3389/fncel.2017.00024. PMCID: PMC5303749  PMID: 28243193

2. Hanslik K, Marino K, Ulland T. (2021) Modulation of Glial Function in Health, Aging, and Neurodegenerative Disease. Front Cell Neurosci. 2021 Aug 31;15:718324. doi: 10.3389/fncel.2021.718324. PMCID: PMC8439422  PMID: 34531726

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