Discover ioCells™
Programmed identity
in every cell
Browse ioCells portfolio
ioWild Type Cells™
ioWild Type Cells are defined, easy-to-use, functional iPSC-derived human cells from a healthy donor background that are ready for fundamental research and drug discovery experimentation within days.
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ioDisease Model Cells™
ioDisease Model Cells are ioWild Type Cells engineered to contain disease-relevant mutations. ioDisease Model Cells and ioWild Type Cells form an isogenic pair allowing scientists to make true comparisons.
Benchtop benefits
Consistent
Our platform ensures consistency between every batch of cells, overcoming the challenge of data reproducibility.
Cost-effective
ioCells generate quality data at industry leading seeding densities. You can do more with every vial as every well saves you money.
Defined
Every ioCell has its identity characterised by ICC, RT-qPCR and RNA-Seq at minimum.
Easy-to-use
ioCells are delivered cryopreserved and require a simple protocol using an open-source medium to get started.
Quick
Precision reprogrammed cells mature rapidly, meaning cells are ready for experimentation and data gathering within days post-revival.
Scalable
With opti-ox technology we can make billions of consistently reprogrammed cells, surpassing the demands of industrial workflows.
Our precision reprogramming technology
Every ioCell is powered by opti-ox.
With opti-ox, we take inducible genetic programs that are coded to define cell fate, and integrate them into regions of the genome that are not affected by gene silencing. This precise control drives a programmed identity in every cell, and means human iPSCs can be reprogrammed into any cell type.
Each vial of ioCells contains a defined and known cell identity and purity. Consistency between batches eliminates the need to re-validate for every experiment. As a result, ioCells are ready for quality data production in a matter of days.
Custom cell development
Partner with us. Access our cell identity coding platform to generate custom ioCells precision reprogrammed to precisely answer your drug discovery, cell therapy or disease research questions.
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Development and characterisation of a robust in vitro disease model to study tauopathies
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Validation of ALS-relevant phenotypes in precision reprogrammed iPSC-derived glutamatergic Neurons containing a TDP-43 M337V mutation.
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Interferon-γ exposure of human iPSC-derived neurons alters major histocompatibility complex I and synapsin protein expression | Publication
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Glutamatergic Neurons and Brain Cyst Formation | Publication
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Compounds co-targeting kinases in axon regulatory pathways promote regeneration and behavioral recovery after spinal cord injury in mice | Publication
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Modelling neurodevelopment | Investigating the impact of maternal immune activation on neurodevelopment using human stem cell models
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Partnering with Charles River to advance CNS drug discovery with ioGlutamatergic Neurons™
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In Conversation with Charles River
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Stem Cells and Functional Genomic Screening | Talk
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High Content Analysis of 2D and 3D cellular models for target and phenotypic drug discovery
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Consistent and scalable human iPSC-derived cells for in vitro disease modelling and drug discovery
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Molecular and functional characterization of stem cells-derived glutamatergic neurons in support of drug discovery applications
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