Discover ioCells

Programmed identity
in every cell

Mature, functional human
iPSC-derived cells within days,
powered by opti-ox™

The future of human health will be defined by technologies that accelerate the world's access to more effective medicines.

Human cells are a cornerstone of fundamental disease research, drug discovery, and clinical translation. Yet, despite decades of research into iPSCs, emerging cures for some of the world’s most pervasive diseases have been bottlenecked by a lack of access to standardised, easy to use and readily accessible human cells.

We built ioCells to solve this challenge.

Developed on our platform, and powered by opti-ox technology, ioCells are human cells precision reprogrammed from iPSCs consistently, at scale. With ioCells, scientists no longer need to battle with variance, unreliability, physiological irrelevance and long experimental timelines. Instead, scientists can finally focus on the next great advances in human health.

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Browse ioCells portfolio

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ioWild Type Cells™

ioWild Type Cells are defined, easy-to-use, functional iPSC-derived human cells from a healthy donor background that are ready for fundamental research and drug discovery experimentation within days.

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ioDisease Model Cells™

ioDisease Model Cells are ioWild Type Cells engineered to contain disease-relevant mutations. ioDisease Model Cells and ioWild Type Cells form an isogenic pair allowing scientists to make true comparisons.

Characteristics that inspire confidence

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Consistent

Our platform ensures consistency between every batch of cells, overcoming the challenge of data reproducibility.

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Cost-effective

ioCells generate quality data at industry leading seeding densities. You can do more with every vial as every well saves you money.

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Defined

Every ioCell has its identity characterised by ICC, RT-qPCR and RNA-Seq at minimum.

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Easy-to-use

ioCells are delivered cryopreserved and require a simple protocol using an open-source medium to get started.

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Quick

Precision reprogrammed cells mature rapidly, meaning cells are ready for experimentation and data gathering within days post-revival.

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Scalable

With opti-ox technology we can make billions of consistently reprogrammed cells, surpassing the demands of industrial workflows.

Our latest cells

ioGlutamatergic Neurons MAPT N279K/WT™ ioDisease Model
ioGlutamatergic Neurons MAPT N279K/WT™ cat no. io1009
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ioGlutamatergic Neurons MAPT P301S/WT™ ioDisease Model
ioGlutamatergic Neurons MAPT P301S/WT™ cat no. io1015
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ioGlutamatergic Neurons MAPT P301S/P301S™ ioDisease Model
ioGlutamatergic Neurons MAPT P301S/P301S™ cat no. io1018
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ioMicroglia™ ioWild Type
ioMicroglia™ cat no. ioA021
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ioGlutamatergic Neurons TDP-43 M337V™ ioDisease Model
ioGlutamatergic Neurons TDP-43 M337V™ cat no. ioEA1005 | ioEA1006
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ioGABAergic Neurons™ ioWild Type
ioGABAergic Neurons™ cat no. ioEA1003S
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ioSkeletal Myocytes™ ioWild Type
ioSkeletal Myocytes™ cat no. io1002
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ioGlutamatergic Neurons HTT50CAG/WT™ ioDisease Model
ioGlutamatergic Neurons HTT50CAG/WT™ cat no. ioEA1004
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ioGlutamatergic Neurons™ ioWild Type
ioGlutamatergic Neurons™ cat no. io1001
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Our precision reprogramming technology

opti-ox

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Every ioCell is powered by opti-ox.

With opti-ox, we take inducible genetic programs that are coded to define cell fate, and integrate them into regions of the genome that are not affected by gene silencing. This precise control drives a programmed identity in every cell, and means human iPSCs can be reprogrammed into any cell type.

Each vial of ioCells contains a defined and known cell identity and purity. Consistency between batches eliminates the need to re-validate for every experiment. As a result, ioCells are ready for quality data production in a matter of days. 

Custom cell development

Partner with us. Access our cell identity coding platform to generate custom ioCells precision reprogrammed to precisely answer your drug discovery, cell therapy or disease research questions.

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Product resources

Interferon-γ exposure of human iPSC-derived neurons alters major histocompatibility complex I and synapsin protein expression Publication
Interferon-γ exposure of human iPSC-derived neurons alters major histocompatibility complex I and synapsin protein expression

Pavinlek., et al | Frontiers in Psychiatry

2022

 

Using ioGlutamatergic Neurons

 

 

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Depletion of Intracellular Glutamine Pools Triggers Toxoplasma gondii Stage Conversion in Human Glutamatergic Neurons Publication
Depletion of Intracellular Glutamine Pools Triggers Toxoplasma gondii Stage Conversion in Human Glutamatergic Neurons

Bando., et al | Frontiers in Cellular and Infection Microbiology

2022

 

Using ioGlutamatergic Neurons

 

 

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Compounds co-targeting kinases in axon regulatory pathways promote regeneration and behavioral recovery after spinal cord injury in mice Publication
Compounds co-targeting kinases in axon regulatory pathways promote regeneration and behavioral recovery after spinal cord injury in mice

Mah., et al | Experimental Neurology

2022

 

Using ioGlutamatergic Neurons

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Modelling neurodevelopment | Investigating the impact of maternal immune activation on neurodevelopment using human stem cell models Webinar
Modelling neurodevelopment | Investigating the impact of maternal immune activation on neurodevelopment using human stem cell models

Dr Deepak Srivastava | King’s College London

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Partnering with Charles River to advance CNS drug discovery with ioGlutamatergic Neurons™ Video
Partnering with Charles River to advance CNS drug discovery with ioGlutamatergic Neurons™

Charles River

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In Conversation with Charles River Video
In Conversation with Charles River

Dr Marijn Vlaming | Head of Biology
Charles River

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CRISPR and the Art of Perturbation Screening: Unbiased functional genomic screening meets the best human cellular models Talk
CRISPR and the Art of Perturbation Screening: Unbiased functional genomic screening meets the best human cellular models

Kam Dhaliwal | SVP Strategic Alliances


Talk at ELRIG CRISPR in Drug Discovery

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High Content Analysis of 2D and 3D cellular models for target and phenotypic drug discovery Poster
High Content Analysis of 2D and 3D cellular models for target and phenotypic drug discovery

Lachize | et al
Courtesy of Charles River Laboratories

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Consistent and scalable human iPSC-derived cells for in vitro disease modelling and drug discovery Talk
Consistent and scalable human iPSC-derived cells for in vitro disease modelling and drug discovery

Kam Dhaliwal SVP Strategic Alliances
Dr Thomas Moreau | Head of Research


Talk at ELRIG Drug Discovery Digital

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Molecular and functional characterization of stem cells-derived glutamatergic neurons in support of drug discovery applications Poster
Molecular and functional characterization of stem cells-derived glutamatergic neurons in support of drug discovery applications

Iovino | et al
Courtesy of Charles River

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Related pages

Resources Explore our latest scientific insights, webinars, blogs and videos
Our platform Discover the cell identity coding platform that powers our ioCells
News Read our latest updates and press coverage