Talk
In Vitro Approaches to Neurodegeneration: Characterisation of ioGlutamatergic Neurons as PD models
Learn how Dr Perez Ruiz, Scantox Neuro, is using human iPSC-derived ioGlutamatergic Neurons carrying SNCA and GBA mutations to uncover functional differences linked to familial and sporadic Parkinson’s disease.
Learn how Dr Perez Ruiz, Scantox Neuro, is using human iPSC-derived ioGlutamatergic Neurons carrying SNCA and GBA mutations to uncover functional differences linked to familial and sporadic Parkinson’s disease.
Specific mutations in the SNCA gene, which encode α-synuclein, increase the risk of familial Parkinson’s disease (PD). Additionally, GBA gene mutations which affect glucocerebrosidase enzyme activity, are associated with sporadic and familial forms of PD, impacting lysosomal function and causing neurodegeneration. This talk summarises the experiments performed to characterize iPSC-derived glutamatergic neurons with SNCA A53T mutations and various GBA gene defects, comparing them to wild type (WT) control neurons.