Amyloid-beta Induces Toxicity and Cell Death in Human iPSC-derived Neurons: Alzheimer Disease In Vitro Model

Abstract

Alzheimer’s is a genetic chronic neurodegenerative disease that typically begins around the age of 60 and progressively impairs cognition and language. A key common hallmark is the accumulation of plaques containing β-amyloid that leads to synaptic failure and, eventually, neuronal death.

In recent years, reproducing and studying the mechanisms behind Alzheimer’s disease’s (AD) pathology and β-amyloid plaques-dependent degeneration have been facilitated by the advent of induced pluripotent stem cells (iPSCs).

The goal of the current study is to develop a robust AD in vitro model, based on the treatment of iPSC-derived glutamatergic neurons with commercially available β-amyloid aggregates.

This poster is courtesy of Charles River Laboratories