A robust platform of human iPSC-derived motor neurons for ALS disease modelling and neurodegeneration-focussed drug discovery

You will learn:

• opti-ox technology reliably produces hiPSC-derived motor neurons, a homogenous population of defined and functional cells

• Genetically matched disease models were engineered to carry ALS- and FTD- relevant mutations. Our panel of disease-relevant mutations in ioMotor Neurons will help to understand the similarities and differences between the molecular mechanisms causing ALS and FTD

• CRISPRko-Ready ioMotor Neurons are defined human lower motor neurons constitutively expressing Cas9, ready for knockout experiments from day 3.