ioDisease Model Cells

ioDisease Model Cells

Human iPSC-derived disease models

ioDisease Model Cells are a range of precision reprogrammed human iPSC-derived cells engineered to contain disease-relevant mutations. Each ioDisease Model Cell can be paired with a genetically matched ioWild Type Cell, forming an isogenic pair that helps scientists make true comparisons in their data.

ioCells are for research use only.

Alzheimer's disease models

ioMicroglia TREM2 R47H/WT ioDisease Model Cells
ioMicroglia TREM2 R47H/WT cat no. io1038
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ioMicroglia TREM2 R47H/R47H ioDisease Model Cells
ioMicroglia TREM2 R47H/R47H cat no. io1035 | io1036
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ioMicroglia APOE 4/3 C112R/WT ioDisease Model Cells
ioMicroglia APOE 4/3 C112R/WT cat no. io1033 | io1034
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ioMicroglia APOE 4/4 C112R/C112R ioDisease Model Cells
ioMicroglia APOE 4/4 C112R/C112R cat no. io1031 | io1032
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ioGlutamatergic Neurons APP KM670/671NL Hom ioDisease Model Cells
ioGlutamatergic Neurons APP KM670/671NL Hom cat no. io1059
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ioGlutamatergic Neurons APP KM670/671NL Het ioDisease Model Cells
ioGlutamatergic Neurons APP KM670/671NL Het cat no. io1060 | io1061 | io1062
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ioGABAergic Neurons APP V717I/WT ioDisease Model Cells
ioGABAergic Neurons APP V717I/WT cat no. io1084 | io1085
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ioGABAergic Neurons APP V717I/V717I ioDisease Model Cells
ioGABAergic Neurons APP V717I/V717I cat no. io1081 | io1082
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ioGlutamatergic Neurons PSEN1 M146L/WT ioDisease Model Cells
ioGlutamatergic Neurons PSEN1 M146L/WT cat no. io1072 | io1073 | io1074
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ioGlutamatergic Neurons PSEN1 M146L/M146L ioDisease Model Cells
ioGlutamatergic Neurons PSEN1 M146L/M146L cat no. io1069 | io1070 | io1071
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ioGlutamatergic Neurons APP V717I/WT ioDisease Model Cells
ioGlutamatergic Neurons APP V717I/WT cat no. io1067 | io1068
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ioGlutamatergic Neurons APP V717I/V717I ioDisease Model Cells
ioGlutamatergic Neurons APP V717I/V717I cat no. io1063 | io1064 | io1065
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Parkinson's and Gaucher disease models

ioGlutamatergic Neurons PRKN R275W/WT ioDisease Model Cells
ioGlutamatergic Neurons PRKN R275W/WT cat no. io1013
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ioGlutamatergic Neurons PRKN R275W/R275W ioDisease Model Cells
ioGlutamatergic Neurons PRKN R275W/R275W cat no. io1020
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ioGlutamatergic Neurons PINK1 Q456X/WT ioDisease Model Cells
ioGlutamatergic Neurons PINK1 Q456X/WT cat no. io1078 | io1079 | io1080
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ioGlutamatergic Neurons PINK1 Q456X/Q456X ioDisease Model Cells
ioGlutamatergic Neurons PINK1 Q456X/Q456X cat no. io1075 | io1076
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ioGlutamatergic Neurons SNCA A53T/A53T ioDisease Model Cells
ioGlutamatergic Neurons SNCA A53T/A53T cat no. io1087 | io1088 | io1089
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ioGlutamatergic Neurons GBA null/R159W ioDisease Model Cells
ioGlutamatergic Neurons GBA null/R159W cat no. io1007
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ALS and FTD disease models

ioGlutamatergic Neurons TDP‑43 M337V/WT ioDisease Model Cells
ioGlutamatergic Neurons TDP‑43 M337V/WT cat no. ioEA1006
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ioGlutamatergic Neurons TDP‑43 M337V/M337V ioDisease Model Cells
ioGlutamatergic Neurons TDP‑43 M337V/M337V cat no. ioEA1005
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ioGlutamatergic Neurons MAPT P301S/WT ioDisease Model Cells
ioGlutamatergic Neurons MAPT P301S/WT cat no. io1015
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ioGlutamatergic Neurons MAPT P301S/P301S ioDisease Model Cells
ioGlutamatergic Neurons MAPT P301S/P301S cat no. io1008
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ioGlutamatergic Neurons MAPT N279K/WT ioDisease Model Cells
ioGlutamatergic Neurons MAPT N279K/WT cat no. io1009
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ioGlutamatergic Neurons MAPT N279K/N279K ioDisease Model Cells
ioGlutamatergic Neurons MAPT N279K/N279K cat no. io1014
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Huntington's disease models

ioGlutamatergic Neurons HTT 50CAG/WT ioDisease Model Cells
ioGlutamatergic Neurons HTT 50CAG/WT cat no. ioEA1004
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Duchenne Muscular Dystrophy disease models

ioSkeletal Myocytes DMD Exon 44 Deletion ioDisease Model Cells
ioSkeletal Myocytes DMD Exon 44 Deletion cat no. io1018
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ioSkeletal Myocytes DMD Exon 52 Deletion ioDisease Model Cells
ioSkeletal Myocytes DMD Exon 52 Deletion cat no. io1019
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Wild type and isogenic disease model cells: A true comparison

Be confident in your data by pairing ioDisease Model Cells with the genetically matched ioWild Type control.

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The right human model

Are you seeking to solve the paucity of successful treatments for neurodegenerative disease? Learn how ioDisease Model Cells are being used as a physiologically-relevant CNS model for drug discovery that will reproducibly scale to high-throughput screens.

“Ultimately, we hope our ioDisease Model Cells will help provide more effective therapies for neurodegenerative diseases such as Huntington’s disease. I believe that it is crucial to use the right human model to successfully translate research into the clinic and help patients”

TonyTony Oosterveen PhD 
bit.bio

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A next-generation approach to study Huntington’s disease

Learn about the benchtop benefits and applications of our latest disease model for Huntington’s disease, ioGlutamatergic Neurons HTT 50CAG/WT.

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Addressing current challenges of in vitro cell models

Discover how experts from across academia and industry are approaching the challenges of accuracy and reproducibility of in vitro cell models as well as potential solutions.

“For translational applications, it’s important to identify a model that is relevant, which is mirroring the human disease”

Bit.bio_circle_headshot_Pic0004-removebg-preview (2)Davide Danovi PhD 
King’s College London

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Don’t see what you’re looking for? 

Partner with us to generate custom ioDisease Model Cells. Access our platform to generate custom disease model cells to answer your drug discovery and disease research questions.

Giving you easy access to the best cells

Related pages

Discover ioCells Learn about our range of human iPSC-derived cells for research and drug discovery
Resources Explore our latest scientific insights, webinars, blogs and videos
Our platform Discover the cell identity coding platform behind our cells