ioDisease Model Cells

ioDisease Model Cells

Human iPSC-derived disease models

ioDisease Model Cells are a range of precision reprogrammed human iPSC-derived cells engineered to contain disease-relevant mutations. Each ioDisease Model Cell can be paired with a genetically matched ioWild Type Cell™, forming an isogenic pair that helps scientists make true comparisons in their data.

ioCells are for research use only.

Browse our portfolio

ioGlutamatergic Neurons MAPT N279K/WT™ ioDisease Model
ioGlutamatergic Neurons MAPT N279K/WT™ cat no. io1009
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ioGlutamatergic Neurons MAPT P301S/WT™ ioDisease Model
ioGlutamatergic Neurons MAPT P301S/WT™ cat no. io1015
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ioGlutamatergic Neurons MAPT P301S/P301S™ ioDisease Model
ioGlutamatergic Neurons MAPT P301S/P301S™ cat no. io1018
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ioGlutamatergic Neurons HTT 50CAG/WT™ ioDisease Model
ioGlutamatergic Neurons HTT 50CAG/WT™ cat no. ioEA1004
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Wild type and isogenic disease model cells: A true comparison

Be confident in your data by pairing ioDisease Model Cells with the genetically matched ioWild Type control.


The right human model

Are you seeking to solve the paucity of successful treatments for neurodegenerative disease? Learn how ioDisease Model Cells are being used as a physiologically-relevant CNS model for drug discovery that will reproducibly scale to high-throughput screens.

“Ultimately, we hope our ioDisease Model Cells will help provide more effective therapies for neurodegenerative diseases such as Huntington’s disease. I believe that it is crucial to use the right human model to successfully translate research into the clinic and help patients”

TonyTony Oosterveen PhD


A next-generation approach to study Huntington’s disease

Learn about the benchtop benefits and applications of our latest disease model for Huntington’s disease, ioGlutamatergic Neurons HTT 50CAG/WT.

Gradient Neuron CGAT 2

Addressing current challenges of in vitro cell models

Discover how experts from across academia and industry are approaching the challenges of accuracy and reproducibility of in vitro cell models as well as potential solutions.

“For translational applications, it’s important to identify a model that is relevant, which is mirroring the human disease”

Bit.bio_circle_headshot_Pic0004-removebg-preview (2)Davide Danovi PhD 
King’s College London

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Don’t see what you’re looking for? 

Partner with us. Access our platform to generate custom precision reprogrammed disease model cells to precisely answer your drug discovery, cell therapy or disease research questions.

Giving you easy access to the best cells

Related pages

Discover ioCells Learn about our range of human iPSC-derived cells for research and drug discovery
Resources Explore our latest scientific insights, webinars, blogs and videos
Our platform Discover the cell identity coding platform behind our cells