cat no | io1007
ioGlutamatergic Neurons
GBA null/WT™
Human iPSC-derived Gaucher and Parkinson’s disease model
ioGlutamatergic Neurons GBA null/WT are opti‑ox™ precision reprogrammed glutamatergic neurons carrying a genetically engineered heterozygous knockout of the GBA gene encoding the glucocerebrosidase (GCase) enzyme. The cells offer a suitable model to study the molecular and cellular processes seen in Gaucher and Parkinson’s diseases.
Related disease model cells are coming soon with a heterozygous PRKN R275W or a homozygous PRKN R275W mutation. All can be used alongside their genetically matched control, ioGlutamatergic Neurons™.
Coming Soon
Register your interest, and we will notify you as soon as the product is available.
Benchtop benefits
Make True Comparisons
Pair the ioDisease Model Cells with the genetically matched wild-type ioGlutamatergic Neurons to investigate the impact of the mutation.
Scalable
With opti-ox technology, we can make billions of consistently reprogrammed cells, surpassing the demands of industrial workflows.
Quick
The disease model cells and isogenic control are experiment ready as early as 2 days post revival, and form structural neuronal networks at 11 days.
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Precision Cellular Reprogramming for Scalable and Consistent Human Neurodegenerative Disease Models
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Development and characterisation of a robust in vitro disease model to study tauopathies
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Validation of ALS-relevant phenotypes in precision reprogrammed iPSC-derived glutamatergic Neurons containing a TDP-43 M337V mutation.
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Partnering with Charles River to advance CNS drug discovery with ioGlutamatergic Neurons™
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Culturing Glutamatergic Neurons | How-to Video
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Preparing Culture Vessels for Glutamatergic Neurons | How-to Video
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In Conversation with Charles River
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Addressing current challenges of in vitro cell models
Read this blog to find out how experts from across academia and industry are approaching the challenges of reproducibility of in vitro cell models as well as potential solutions.
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Wild Type and Isogenic Disease Model cells: A true comparison.
Further your disease research by pairing our wild type cells with isogenic disease models.
