Synaptophysin autoantibodies mediate synaptic dysfunction in cerebellar ataxia

Read the publication to explore:

• The identification of synaptophysin (SYP) as an autoantigen in cerebellar ataxias (CA) using serum IgG staining, human protein array, and cell-based assays

• How exposure of human iPSC-derived glutamatergic neurons to patient’s IgG with SYP antibodies causes selective SYP accumulation at the presynaptic membrane

• Findings showing that patient’s IgG and SYP monoclonal antibodies reduce neuronal activity recorded by multi-electrode array, uncovering a mechanism of antibody-mediated synaptic dysfunction

• How ioGlutamatergic Neurons were used