Primary human and iPSC-derived myocytes exhibit distinct myogenic profiles in 2D and 3D bioengineered cultures

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• A comparison of commercially available hiPSC-derived ioSkeletal Myocytes with primary human skeletal muscle cells (HDMCs) for markers of cellular morphology and genetics, across 2D monolayers and 3D bioengineered tissues

• How ioSkeletal Myocytes activated myogenic programmes and expressed contractile proteins, with myosin heavy chain coverage comparable to HDMCs

• The use of ioSkeletal Myocytes as a reproducible platform for modelling early myogenesis and high-throughput screening of myogenic specification pathways, with HDMCs suited to studies requiring structural maturation

• How ioSkeletal Myocytes were used