NRN1 as a therapeutic target for Alzheimer's disease

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• The identification of Neuritin-1 (NRN1) as a synaptic protein associated with cognitive resilience to Alzheimer’s disease, with a TREAT-AD target risk score of 3.29
• Single-nucleus RNA sequencing data reveal that NRN1 expression in excitatory neurons tends to decrease with disease progression
• Antibody characterisation demonstrating that NRN1 likely forms a homodimer and maintains comparable protein abundance among controls and primary tauopathy cases, as well as Tau P301S mouse models
• How ioGlutamatergic Neurons and ioAstrocytes were used