Programming brain cell-type-selective delivery in vivo with transporter-guided therapeutics

Read the publication to explore:

• The development of ExACT, a platform for cell-type-selective intracellular delivery that exploits membrane transporters

• How in vivo screening of fluorescent small-molecule libraries in mouse brain identified compounds with preferential entry into neurons, astrocytes, pericytes and endothelial cells

• How the human transporter SLCO1A2 mediated selective uptake in a humanized mouse model and human iPSC-derived oligodendrocytes

• How bifunctional compounds linking transporter-targeting motifs to antisense oligonucleotides or small-molecule drugs retained pharmacological activity while conferring cell-type selectivity

• How ioOligodendrocyte-like cells were used