Publication
Levetiracetam therapeutically targets GABAergic synapses in diffuse midline glioma
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Clinical data showing longer overall survival for children with diffuse midline glioma (DMG) who were taking levetiracetam
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How levetiracetam reduces glioma proliferation and tumor burden, extending survival of mice bearing DMG orthotopic xenografts
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How levetiracetam attenuates low-frequency GABAergic synaptic transmission in a glioma-specific manner, independent of its action on SV2A
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How ioGABAergic Neurons were used
Barron T, et al.
Nature Medicine
2026