Publication
Efficient genome editing in the non-human primate brain using programmable extracellular vesicles
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How single-guide RNA scaffold architecture improves ribonucleoprotein (RNP) stability and, combined with extracellular vesicle (EV) engineering, leads to an increase in potency
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How engineered EVs enabled efficient base editing or knockout in primary cells, human brain organoids and in vivo, including the mouse brain
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How EVs programmed to disrupt MSH3, a key mediator of the somatic CAG expansion underlying Huntington’s disease progression, achieved efficient genome editing in the non-human primate brain
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How ioGlutamatergic Neurons were used
Liang X, et al.
bioRxiv | Preprint
2026