ioHepatocytes are human iPSC-derived hepatocytes, deterministically programmed using opti-ox technology. The cells display a cobblestone morphology, prominent nuclei and expression of core hepatocyte markers from day 4. The cells express phase I-III drug metabolism genes and maintain functional CYP3A, CYP2B6, and CYP1A2 enzymes to support advanced metabolic investigations. ioHepatocytes (Toxicology) also demonstrate DILI responses comparable to primary human hepatocytes, providing a highly predictive platform for hepatotoxicity assessment.
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