Schizophrenia risk gene ZNF804A controls ribosome localization and synaptogenesis in developing human neurons
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Schizophrenia risk gene ZNF804A controls ribosome localization and synaptogenesis in developing human neurons

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Read the publication to explore:

  • The effects of reduced ZNF804A expression on developing cortical glutamatergic neurons derived from isogenic human iPSCs

  • Findings revealing increased excitatory synapse density and altered local protein synthesis efficiency in mutant neurons

  • Proteomic analysis demonstrating elevated levels of ribosomal and translational proteins within neurites of mutant neurons

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Sichlinger, et al

bioRxiv

2024

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