04.05.2023 | Published by Mekonos

Collaborating with Mekonos to advance non-viral cell engineering

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New collaboration combines the Mekonos novel ex vivo delivery platform with bit.bio’s unique opti-ox™ precision cellular reprogramming technology

SAN FRANCISCO, 4th May 2023Mekonos, Inc. a biotech platform company building the future of cell therapies on a chip, has announced a new research collaboration with bit.bio.   

The collaboration will test and optimise non-viral delivery of bit.bio’s patented safe harbour gene-targeting approach which is used to inducibly express transcription factor combinations to reprogram human induced pluripotent stem cells (iPSCs) to accelerate the development of human cells for research, drug discovery and next-generation cell therapies. 

"The combination of Mekonos’ unique, silicon chip-based delivery platform with bit.bio’s leading cellular reprogramming technologies will enable powerful new levels of precision and efficiency in the engineering of iPSCs. We are excited to partner with the world-class team at bit.bio – leaders in synthetic biology and the engineering of human cells – and to leverage Mekonos’ unique non-viral platform for ex-vivo delivery of reprogramming factors to engineer human cells at unprecedented scale and efficiency."



Jake Lesnik

Mekonos VP of Business Development


Developing this approach as an alternative to viral vector delivery will enable bit.bio to precisely engineer stem cells into any mature, functional human cell type with higher efficiency, speed and control.

"Efficient delivery and targeted integration of genetic payloads will be a critical step in manufacturing clinical grade iPSCs for cell therapies. Together with bit.bio’s cellular reprogramming approach, iPSCs have the potential to enable access to allogeneic cell therapies at an affordable cost and to manufacture them as ‘off the shelf’ products. We are optimistic this collaboration will help unlock new opportunities for efficiency in the iPSC engineering process that further advance our cell therapy development."



Mark Kotter

bit.bio Founder and CEO 


Initial results stemming from the research collaboration are expected mid-year. Read more about our opti-ox technology and platform here

About Mekonos, Inc.

Mekonos is an enabling technology company transforming synthetic biology and personalized medicine. The company's ex vivo delivery platform merges innovations in semiconductor, microfluidics, and chemistry for controlled and individualized molecular delivery in cells at scale. The company is headquartered in San Francisco, is backed by leading investors in both healthcare and technology, and was named a 2018 Fierce 15 Startup. For more information, please visit their website.  

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