Impact of SNCA A53T and GBA gene mutations on neurite outgrowth and response to Parkinson's disease stressors in iPSC-derived neurons

You will learn:

• Human iPSC-derived glutamatergic neurons with specific SNCA A53T and GBA mutations provide a consistent human platform to study familial and sporadic Parkinson’s disease.
• Morphometric characterisation allows for the monitoring of neurite outgrowth over time, enabling the study of structural neurodegeneration and lysosomal function
• Predictive toxicology applications are supported by mitochondrial activity (TMRM) and viability (MTT) assays, which measure the functional response of neurons to Parkinson's disease-inducing agents like MPP+ and rotenone