Your mutation of interest in our opti-ox™ powered human iPSC-derived cells
With this custom offering, you can now order your mutation of choice in bit.bio’s opti-ox™ powered human-iPSC derived cells and receive consistent, defined, cryopreserved disease models that can be immediately incorporated into your experiments.
Every custom disease model comes with a genetically matched control, ioWild Type Cells™, giving you confidence that even subtle variances in your data are attributable to your mutation of interest.
Remove the challenges associated with animal models, patient-derived cells and directed differentiation protocols from your workflows, and start collecting disease-relevant data you can trust in a human context. Each project begins as a conversation with our experts about your custom disease model needs.
Build your custom disease model into these wild type cell backgrounds. Use the genetically matched control in your experiments to make true comparisons in your data, and confidently link genotype to phenotype.
"The access to better human cell-based in vitro disease models as generated within our partnership is transformational for the way we do drug discovery with our pharma and biotech clients. We can now provide discovery studies in human stem cell-based assays, where previously we would only do this in for example immortalised cell lines or more simple assay types.”
Marijn Vlaming, PhD
Charles River Laboratories
Identifying intrinsic, observable phenotypes in ioDisease Model Cells has the potential to streamline compound testing in drug discovery by reducing the need to induce disease-related phenotypes when modelling specific diseases. Discover the data generated by our industry partners below.
Our disease models of tau dysfunction show a tau hyperphosphorylation phenotype important to frontotemporal dementia research.