Dynein and dynactin move long-range but are delivered separately to the axon tip

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• The development of a model to study axonal transport using opti-ox™ enabled glutamatergic neurons with endogenously tagged dynein motor components

• High-resolution HILO imaging revealing that dynein, dynactin, and regulators LIS1 and NDEL1 undergo long-distance retrograde movement

• Findings that dynein/LIS1 and dynactin/NDEL1 show distinct anterograde velocities, suggesting they are transported on different cargoes