German Stem Cell Network

We are exhibiting at this event!

Come and visit our team at our stand #5 to discuss how bit.bio offers partnering opportunities that affords access to the most relevant parental human cell types and corresponding disease models. These models are physiologically relevant and highly characterised, offering predictive, in vitro, human cells for early drug discovery, phenotypic screening, and high-content imaging applications.

Listen to Malathi Raman, Product Manager, bit.bio talk on 'Rapid and consistent generation of functional hiPSC-derived microglia to accelerate drug discovery for neurodegenerative diseases'. In this talk, Dr Malathi Raman will discuss the development of bit.bio’s human iPSC-derived ioMicroglia, generated using the ground-breaking opti-ox™ precision cellular reprogramming technology. Dr Raman will present characterisation data that showcases ioMicroglia as a physiologically relevant human-based cellular model to explore neurodegenerative diseases. ioMicroglia, 10 days post-revival, display typical ramified morphology and express key markers including TMEM119, P2RY12, IBA1 and TREM2. RNA sequencing data demonstrates that ioMicroglia have a transcriptomic signature similar to primary adult and foetal microglia. 

We will also be presenting posters on:

• 'Modelling neurodegeneration using a human isogenic system: A next generation approach to study frontotemporal dementia and amyotrophic lateral sclerosis'
• 'Rapid and consistent generation of functional hiPSC-derived microglia to accelerate drug discovery for neurodegenerative diseases'