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Bench-top benefits of ioAstrocytes
Co-culture ready
ioAstrocytes support functional neuronal networks within co-culture settings, enabling in-vitro modelling of complex CNS biology.
Functional
Display key phagocytic and cytokine secretion functions as well as a demonstrable influence on neuronal network activity.
Consistent
Get reproducible results from every vial with lot-to-lot consistency of highly characterised & defined human iPSC-derived cells.
Defined, functional human iPSC-derived astrocytes to enhance in-vitro CNS models
ioAstrocytes are designed for ease of use, supported by open-source media and protocols for co-culturing with other CNS cell types, such as ioGlutamatergic Neurons. Powered by opti-ox deterministic cell programming, these highly characterised astrocytes display stellate morphology and key marker expression by day 8. They effectively recapitulate human astrocyte functions, including phagocytosis, cytokine secretion, and modulation of neuronal activity in CNS co-culture.
ioAstrocytes and ioGlutamatergic Neuron co-culture
Immunocytochemistry image of ioAstrocytes and ioGlutamatergic Neurons in co-culture; staining shows expression of pan-neuronal marker MAP2 (green), astrocyte marker S100B (purple) and DAPI nuclear staining (blue).
