Modelling neurodevelopment | Investigating the impact of maternal immune activation on neurodevelopment using human stem cell models

Human induced pluripotent stem cell (hiPSC)-derived neurons are a must have tool for scientists working in research and drug discovery, they provide a physiologically relevant system to study neurological activity and disease. But it’s consistency, reliability and scalability that is lacking in commonly used hiPSC reprogramming methods.

A new class of cells have been developed using a next-generation reprogramming technology, opti-ox^TM. opti-ox enables the deterministic induction of a new cell identity from hiPSCs, consistently, on a vast scale; resulting in mature, functional hiPSC-derived cells within days.

Learning outcomes:

• Various methods used to generate neuronal cultures from hiPSCs
• How next-generation reprogramming technology can overcome the bottlenecks of traditional methods of cell generation to generate consistent, mature, functional glutamatergic neurons
• The impact of interferon gamma on the neurodevelopment of glutamatergic neuron