Dr. Mariangela Iovino, Group Leader, Charles River
Dr. Tony Oosterveen, Senior Scientist, bit.bio
With a paucity of successful treatments for neurodegenerative diseases, there remains an urgent need to improve research outcomes and drug discovery efficiencies.
It remains challenging to source physiologically-relevant CNS models that are both scalable and reproducible.
Use of human induced Pluripotent Stem Cell (iPSC)-derived neurons offers a relevant model system, but can be hindered by low scalability, heterogeneous populations and long, complex protocols.
A next-generation cell reprogramming technology, opti-ox™, aims to resolve the inconsistencies and inefficiencies of current cell generation methods to enable the precise, consistent and scalable production of human cells. This technology has been used to develop a range of iPSC-derived ioGlutamatergic Neurons carrying disease-specific mutations. The isogenic pairing offers an efficient and robust system using a simple protocol to study neurodegeneration in vitro.
This webcast describes how this new class of precision reprogrammed disease models, are being incorporated into high-throughput screens and drug discovery workflows.
You will learn about the:
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