Advancements in 3D modeling: Building mature, functional 3D skeletal muscle microtissues in vitro

Translatable in vitro muscle systems are crucial for target drug discovery and for predicting the efficacy of new therapies for muscular dystrophies and neuromuscular diseases. While 3D tissues increase system complexity, they often lack vascularisation in the microenvironment.

This webinar explores an innovative, perfusable organ-on-chip platform that nourishes and stimulates our human iPSC-derived ioSkeletal Myocytes to generate striated and multinucleated 3D skeletal muscle microtissues in less than a week.

Dr Marieke Aarts from Bi/ond and Amanda Turner from bit.bio will discuss methods to accelerate and enhance muscle maturation and contractile response. They will also address the translational potential of this technology for vascularisation and dynamic drug response for research and drug discovery.

Learning outcomes:

• Discover how to culture 3D muscle cell bundles on Bi/ond's perfusable organ-on-chip platform.
• Understand how to measure muscle contractions triggered by electrical stimulation in ioSkeletal Myocytes.
• Learn how you can apply this physiologically relevant, functional system to research, preclinical drug discovery and disease modelling.